Bibliographic record
Abstract
Background: Amino acid sequence homology between human thyroid autoantigens (human thyrotropin receptor, human thyroglobulin, human thyroperoxidase, human sodium iodide symporter) and Borrelia proteins has been reported (1). It has been suggested that Borrelia proteins may be capable of triggering autoimmune thyroid disease in persons with certain HLA-DR alleles (1). Clinical case: A 40-year-old male presented to the Emergency Department (ED) with 3 weeks of worsening night sweats, lethargy, and weakness. He previously had 5 oval shaped spots on his body which had appeared after a recent hiking trip but these had disappeared 1.5 weeks prior to his presentation. He had been experiencing positional chest pain for the 3 days prior to coming to the ED. On admission to the hospital he was found to be febrile and bradycardic with ECG revealing high-grade second-degree type II block. He was started on empiric antibiotics for suspected Lyme disease as he had been hiking in a Lyme endemic area. He also had thyroid indices sent off at the time of presentation which came back consistent with hyperthyroidism. The patient did not endorse neck pain or tenderness, visual symptoms, weight loss, diarrhea, tremors, or palpitations. Anti-TPO antibodies as well as a nuclear medicine thyroid uptake and scan were ordered. His anti-TPO antibodies were positive at 26 IU/mL (n<=6 IU/mL). His uptake at 5 hours of was 0.75%, which is markedly below the lower limit of normal (5%) and as such a thyroid scan could not be performed as there would have been insufficient counts to generate a diagnostic image. His hyperthyroidism was most in keeping with a thyroiditis. As such no thyroid specific treatment was initiated. His Lyme Western Blot IgG eventually returned positive. When he was seen in follow up in outpatient endocrinology clinic, thyroid indices revealed he was hypothyroid, in keeping with the hypothyroid phase often seen in thyroiditis. Conclusion: There are a few studies suggesting borrelia proteins may be capable of triggering autoimmune thyroid disease. This case is supportive of this theory and showcases a presentation of Lyme disease associated thyroiditis. References: (1) Benvenga, S., Guarneri, F. Molecular mimicry and autoimmune thyroid disease. Rev Endocr Metab Disord (2016) 17:485-498.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".