334The assessment of functional cardiovascular health after exercise intervention in young adults born preterm
Notice bibliographique
Résumé
OnBehalf: MUHC CMR Group Background: In spite of advances in neonatal care which allows the first generation of individuals born in extreme prematurity to survive, these individuals present with reduced aerobic capacity in young adulthood; a strong predictor of mortality. Clinical trials have consistently demonstrated overall cardiovascular benefits of exercise training in at-risk and diseased populations. However, whether the cardiovascular impairments associated with preterm birth are reversible through exercise intervention in young adulthood is unknown. Purpose: This study aims to assess whether a supervised exercise intervention of aerobic and resistance training can rescue prematurity-related cardiovascular impairments as assessed by functional CMR parameters. Methods: Eight preterm and six healthy control participants of between 18-29 years of age underwent a Cardiovascular MRI (CMR) scan (3T) both at baseline and after a 14-week duration, 3 times/week supervised exercise intervention of aerobic and resistance training. Function and structural parameters were obtained from standard short-axis SSFP cine images with full-ventricular short-axis coverage. Strain and Time to Peak strain parameters were obtained from short-axis and long-axis SSFP images. Strain response to stress measurements were obtained from SSFP cine images acquired during breathing maneuvers of a 60s period of hyperventilation. Results: There was a significant difference in ejection fraction (p < 0.05), and end-systolic volume indexed to height (LVSVi) (p < 0.05) between the control and pre-term participants at baseline. All of these differences were no longer significant after the exercise intervention. There was a significant increase in myocardial mass after the intervention in both the control participants (p < 0.05), and the preterm participants (p < 0.05). Time to Peak Circumferential (p < 0.01) and Time to Peak Longitudinal (p < 0.01) strain were both decreased in control participants after exercise intervention. Additionally, controls had a significantly more pronounced Global Peak Circumferential strain response to stress when compared to pre-term participants (p < 0.05). After intervention, there was no significant different in strain response between the two participant groups. Conclusions: A supervised exercise intervention of aerobic and resistance training led to improved cardiovascular health and function in pre-term participants. The improvement in strain response to stress, EF, ESV, and LVSVi that resulted in no significant difference in parameters between pre-term and control individuals may indicate an improvement in myocardial functional response following a 13-week exercise program.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,009 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,008 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».