334The assessment of functional cardiovascular health after exercise intervention in young adults born preterm
Bibliographic record
Abstract
OnBehalf: MUHC CMR Group Background: In spite of advances in neonatal care which allows the first generation of individuals born in extreme prematurity to survive, these individuals present with reduced aerobic capacity in young adulthood; a strong predictor of mortality. Clinical trials have consistently demonstrated overall cardiovascular benefits of exercise training in at-risk and diseased populations. However, whether the cardiovascular impairments associated with preterm birth are reversible through exercise intervention in young adulthood is unknown. Purpose: This study aims to assess whether a supervised exercise intervention of aerobic and resistance training can rescue prematurity-related cardiovascular impairments as assessed by functional CMR parameters. Methods: Eight preterm and six healthy control participants of between 18-29 years of age underwent a Cardiovascular MRI (CMR) scan (3T) both at baseline and after a 14-week duration, 3 times/week supervised exercise intervention of aerobic and resistance training. Function and structural parameters were obtained from standard short-axis SSFP cine images with full-ventricular short-axis coverage. Strain and Time to Peak strain parameters were obtained from short-axis and long-axis SSFP images. Strain response to stress measurements were obtained from SSFP cine images acquired during breathing maneuvers of a 60s period of hyperventilation. Results: There was a significant difference in ejection fraction (p < 0.05), and end-systolic volume indexed to height (LVSVi) (p < 0.05) between the control and pre-term participants at baseline. All of these differences were no longer significant after the exercise intervention. There was a significant increase in myocardial mass after the intervention in both the control participants (p < 0.05), and the preterm participants (p < 0.05). Time to Peak Circumferential (p < 0.01) and Time to Peak Longitudinal (p < 0.01) strain were both decreased in control participants after exercise intervention. Additionally, controls had a significantly more pronounced Global Peak Circumferential strain response to stress when compared to pre-term participants (p < 0.05). After intervention, there was no significant different in strain response between the two participant groups. Conclusions: A supervised exercise intervention of aerobic and resistance training led to improved cardiovascular health and function in pre-term participants. The improvement in strain response to stress, EF, ESV, and LVSVi that resulted in no significant difference in parameters between pre-term and control individuals may indicate an improvement in myocardial functional response following a 13-week exercise program.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.009 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.008 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".