PHASE 1B KEYNOTE‐013 STUDY OF PEMBROLIZUMAB IN PATIENTS WITH CLASSIC HODGKIN LYMPHOMA AFTER BRENTUXIMAB VEDOTIN FAILURE: RESULTS OF >4 YEARS OF FOLLOW‐UP
Notice bibliographique
Résumé
outcome with combined modality therapy (CMT) or chemotherapy (CT) only, although relapses occurred in both treatment arms.We analyzed the type of salvage treatment and outcome of these relapsing patients.Methods: In the H10 trial, previously untreated patients, 15-70 years old, with classical supradiaphragmatic stage I-II HL, both favorable (F) and unfavorable (U) according to EORTC/LYSA criteria, were eligible.The primary protocol treatment for earlyPET (after 2xABVD) negative patients consisted of: in F patients, 3xABVD+involved-node radiotherapy (INRT) or 4xABVD; in U patients 4xABVD+INRT or 6xABVD.In 2010, the H10 trial was amended since more early relapses occurred in the CT arm of the trial and from that moment on, all early PETnegative patients received CMT.All earlyPET negative patients who relapsed were included in the current analysis and grouped in the CMT or CT group, dependent of the actually delivered primary treatment.The type of salvage treatment was left to the discretion of the investigator.Second progression/relapse (PFS2) was defined as the time from randomization to objective tumor progression on next-line treatment or death from any cause.Results: Ninety-four earlyPET negative patients relapsed, 28 of those after initial CMT and 66 after CT.Their demographic and disease characteristics are described in table 1.In CMT, almost all relapses occurred in the U group whereas in CT relapses both in F and in U. Regarding salvage treatment, 69 patients received 1 line of treatment, 9 received 2 lines and 15 received 3 lines or more; for one patient, this information is missing.Overall, 66 (71%) patients received autologous stem cell transplantation (ASCT) and 29% received CT and/or RT.After CMT, the first salvage treatment was ASCT in 25/28 patients, while after CT the ASCT was first line salvage in 41/66.Overall, relapsed patients had a similar number of treatment lines whether they were initially treated with CMT or CT, but the type of treatment differed significantly with more ASCT in the CMT group (89.3% vs 63.1%, p = 0.012).There was no significant difference in OS or PFS2 between relapsing patients treated initially with CMT or CT: 3y-OS of 89% (95% CI: 69.7-96.3)vs 93.9% (95% CI: 84.6-97.7 resp.) and PFS2 (3y-PFS2 of 79.6 (95% CI:57.5-91)vs 78% (95% CI:65.7-86.3,resp.).The 3y-PFS2 and OS of patients undergoing ASCT was 62.8% and 93.9% and the 3-y PFS and OS of patients treated with CT and/or RT only was 88.9% and 88.6% respectively. Conclusion:The outcome of earlyPET negative patients relapsing after first line treatment is good, irrespective of initial treatment with CMT or CT.More patient received ASCT as first line salvage in the CMT group.The PFS2 and OS were comparable in patient treated with initial CMT and CT.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».