PHASE 1B KEYNOTE‐013 STUDY OF PEMBROLIZUMAB IN PATIENTS WITH CLASSIC HODGKIN LYMPHOMA AFTER BRENTUXIMAB VEDOTIN FAILURE: RESULTS OF >4 YEARS OF FOLLOW‐UP
Bibliographic record
Abstract
outcome with combined modality therapy (CMT) or chemotherapy (CT) only, although relapses occurred in both treatment arms.We analyzed the type of salvage treatment and outcome of these relapsing patients.Methods: In the H10 trial, previously untreated patients, 15-70 years old, with classical supradiaphragmatic stage I-II HL, both favorable (F) and unfavorable (U) according to EORTC/LYSA criteria, were eligible.The primary protocol treatment for earlyPET (after 2xABVD) negative patients consisted of: in F patients, 3xABVD+involved-node radiotherapy (INRT) or 4xABVD; in U patients 4xABVD+INRT or 6xABVD.In 2010, the H10 trial was amended since more early relapses occurred in the CT arm of the trial and from that moment on, all early PETnegative patients received CMT.All earlyPET negative patients who relapsed were included in the current analysis and grouped in the CMT or CT group, dependent of the actually delivered primary treatment.The type of salvage treatment was left to the discretion of the investigator.Second progression/relapse (PFS2) was defined as the time from randomization to objective tumor progression on next-line treatment or death from any cause.Results: Ninety-four earlyPET negative patients relapsed, 28 of those after initial CMT and 66 after CT.Their demographic and disease characteristics are described in table 1.In CMT, almost all relapses occurred in the U group whereas in CT relapses both in F and in U. Regarding salvage treatment, 69 patients received 1 line of treatment, 9 received 2 lines and 15 received 3 lines or more; for one patient, this information is missing.Overall, 66 (71%) patients received autologous stem cell transplantation (ASCT) and 29% received CT and/or RT.After CMT, the first salvage treatment was ASCT in 25/28 patients, while after CT the ASCT was first line salvage in 41/66.Overall, relapsed patients had a similar number of treatment lines whether they were initially treated with CMT or CT, but the type of treatment differed significantly with more ASCT in the CMT group (89.3% vs 63.1%, p = 0.012).There was no significant difference in OS or PFS2 between relapsing patients treated initially with CMT or CT: 3y-OS of 89% (95% CI: 69.7-96.3)vs 93.9% (95% CI: 84.6-97.7 resp.) and PFS2 (3y-PFS2 of 79.6 (95% CI:57.5-91)vs 78% (95% CI:65.7-86.3,resp.).The 3y-PFS2 and OS of patients undergoing ASCT was 62.8% and 93.9% and the 3-y PFS and OS of patients treated with CT and/or RT only was 88.9% and 88.6% respectively. Conclusion:The outcome of earlyPET negative patients relapsing after first line treatment is good, irrespective of initial treatment with CMT or CT.More patient received ASCT as first line salvage in the CMT group.The PFS2 and OS were comparable in patient treated with initial CMT and CT.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".