<p>First identification of <em>mcr-1/mcr-2</em> genes in the fecal microbiota of Canadian commercial pigs during the growing and finishing period</p>
Notice bibliographique
Résumé
First identification of mcr-1/mcr-2 genes in the fecal microbiota of Canadian commercial pigs during the growing and finishing period Mohamed Rhouma,1 William Thériault,1 Nassima Rabhi,1 Caroline Duchaine,2 Sylvain Quessy,1 Philippe Fravalo11Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada; 2Department of Biochemistry, Microbiology and Bioinformatics, Faculty of Science and Engineering, Université Laval, Québec, QC G1V 4G5, Canada Colistin is considered one of the last-resort antibiotics used for the treatment of infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB) in humans.1 This antibiotic is classified by the World Health Organization, among the category of the Highest Priority Critically Important Antimicrobials for human medicine.2 In this regard, the global dissemination of plasmid-mediated colistin resistance, conferred by themobile colistin resistance (mcr) genes, has raised serious concern among physicians and scientists worldwide.2 On the other hand, colistin has been widely used in food animals in many countries either for disease therapy, prophylaxis or for growth promotion.3 Many studies reported a high prevalence of mcr genes on bacterial isolates from animals' origin compared to humans, and consequently animals, particularly pig production, were pointed out as the greatest cause of bacterial colistin resistance spread.1 In pigs, mcr genes were isolated mainly from colistin resistant E. coli, Salmonella and Klebsiella isolates, with mcr-1 gene being themost frequently identified gene among the eight types of mcr genes currently described.1 Among other Gram-negative bacteria (GNB) of pig origin, mcr genes were identified in Moraxella spp.,4 and in Aeromonas hydrophila,5 enforcing the interest to consider the mcr presence at the microbiota level. In Canada, although colistin is not approved for use in veterinarymedicine, it was sometimes used in pigs according to special precautions for the oral treatment of digestive infections caused by GNB.1 Nevertheless, mcr-1 gene has been identified in E. coli isolated from humans, as well as from lean ground beef in Canada.6 However, to the best of our knowledge, mcr genes have never been identified in animals at the farm level in Canada. Here we reportthe screening of fecal samples obtained from one Canadian commercial pig farm, to determine the prevalence over the growing period of mcr-1 and mcr-2 genes in the fecal microbiota of pigs. Colistin has never been used in this farm. However, tiamulin and chlortetracycline were used in the post-weaning period and salinomycin as well as narasin were used during the growing phase.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,006 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».