Evidence for temperature‐mediated regional increases in cerebral blood flow during exercise
Notice bibliographique
Résumé
Key points Aerobic exercise elicits increases in cerebral blood flow (CBF), as well as core body temperature; however, the isolated influence of temperature on CBF regulation during exercise has not been investigated The present study assessed CBF regulation and neurovascular coupling during submaximal cycling exercise and temperature‐matched passive heat stress during isocapnia (i.e. end‐tidal was held constant) Submaximal cycling exercise and temperature‐matched passive heat stress provoked ∼16% increases in vertebral artery blood flow, independent of changes in end‐tidal and blood pressure External carotid artery blood flow increased by ∼43% during both exercise and passive heat stress, with no change in internal carotid artery blood flow Neurovascular coupling (i.e. the relationship between local increases in cerebral metabolism and appropriately matched increases in regional cerebral blood flow) is preserved during both exercise and temperature‐matched passive heat stress Abstract Acute moderate‐intensity exercise increases core temperature ( T c ; +0.7‐0.8°C); however, such exercise increases cerebral blood flow (CBF; +10‐20%) mediated via small elevations in arterial and metabolism. The present study aimed to isolate the role of T c from on CBF regulation during submaximal exercise. Healthy adults ( n = 11; 10 males/one female; 26 ± 4 years) participated in two interventions each separated by ≥48 h: (i) 60 min of semi‐recumbent cycling (EX; 50% workload max) and (ii) 75 min of passive heat stress (HS; 49°C water‐perfused suit) to match the exercise‐induced increases in T c (EX: Δ0.75 ± 0.33°C vs . HS: Δ0.77 ± 0.33°C, P = 0.855). Blood flow ( Q ) in the internal and external carotid arteries (ICA and ECA, respectively) and vertebral artery (VA) (Duplex ultrasound) was measured. End‐tidal and were effectively clamped to resting values within each condition. The Q ICA was unchanged with EX and HS interventions ( P = 0.665), consistent with the unchanged end‐tidal ( P = 0.327); whereas, Q VA was higher throughout both EX and HS (EX: Δ16 ± 21% vs . HS: Δ16 ± 23%, time effect: P = 0.006) with no between condition differences ( P = 0.785). These increases in Q VA contributed to higher global CBF throughout both EX and HS (EX: Δ12 ± 20% vs . HS: Δ14 ± 14%, time effect: P = 0.029; condition effect: P = 0.869). The Q ECA increased throughout both EX and HS (EX: Δ42 ± 58% vs . HS: Δ53 ± 28%, time effect: P < 0.001; condition effect: P = 0.628). Including blood pressure as a covariate did not alter these CBF findings (all P > 0.05). Overall, these data provide new evidence for temperature‐mediated elevations in posterior CBF during exercise that are independent of changes in and blood pressure.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
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