Standardized High Versus Low Dose Cranberry Proanthocyanidin Extracts for Prevention of Urinary Tract Infection Confirmed by Pyuria in Women: A Randomized Clinical Trial
Notice bibliographique
Résumé
Cranberry products are often used by women to prevent urinary tract infections (UTIs) but literature regarding their efficacy remains discordant. The clinical efficacy of cranberry products for prevention of UTIs in healthy women could be increased by 1) using an optimal dose of cranberry extract standardized in proanthocyanidins (PACs); 2) adequate measure of compliance. The objective of this randomized clinical trial was to assess the efficacy of an optimal dose of cranberry extract standardized in PACs for the prevention of recurrent UTI confirmed by pyuria during a 24-week intervention period. One hundred and forty-five women with a history of recurrent UTI in the past 12 months were randomized to receive a dose of cranberry extract Urophenol™, standardized in PACs (2 × 18.5 mg PACs daily, n = 72) or a control dose (2 × 1 mg PACs daily, n = 73) for a 24-week period. Women were asked to contact the study coordinator if they presented symptoms of UTI and to provide a urine sample to evaluate the diagnosis by confirmation of pyuria. Since some women were unable to provide a urine sample in the presence of UTI symptoms, regression analyses were performed with two different approaches, 1) symptomatic UTI episodes without a urine sample were considered as no symptomatic UTIs with pyuria; 2) symptomatic UTI episodes without a urine sample were considered as symptomatic UTIs with pyuria. Analyses were adjusted for age. No significant differences in the number of symptomatic UTI with pyuria were found between groups during the 24-week intervention period in intention to treat analyses using either approach (approach 1: incidence rate ratio 0.98, 95% CI 0.57–1.68; approach 2: 0.86, 95% CI 0.56–1.32). Among women who experienced less than 5 UTIs in the year preceding enrolment, daily consumption of 2 × 18.5 mg PACs was associated with a decrease in the number of symptomatic UTIs compared to the control dose (approach 1: incidence rate ratio 0.65, 95% CI 0.31–1.37; approach 2: 0.54, 95% CI 0.30–0.99). Compliance to capsule intake was higher than 90% in both groups. In women who experience less than 5 UTIs in the last year, daily consumption of a standardized dose of 2 × 18.5 mg PACs could have a preventative impact on the incidence of symptomatic UTIs confirmed by pyuria. Supported by Diana Foods and MAPAQ.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».