QUALITY OF LIFE AMONG PATIENTS WITH PRIMARY BILIARY CHOLANGITIS DURING CANADA'S STATE OF EMERGENCY RESPONSE TO COVID-19
Notice bibliographique
Résumé
Background: Canadian provinces initiated states of emergency (SoE) between March 13 and March 23 2020 due to community transmission of COVID-19 We explore changes in self-reported quality of life (QoL) in patients with PBC early-on during SoE Methods: Patients with PBC from the Canadian Network for Autoimmune Liver disease who completed QoL questionnaires between July 2019 and June 2020 are included Questionnaires include the Short-Form 36 (SF-36), PBC-40, and Itch Numeric Rating Scale (iNRS) Measurements during SoE are after March 17 2020, date of SoE initiation in Ontario Measurements before Feb 1 2020 are pre-SoE Measurements between Feb 1 and March 16 2020 are excluded given growing societal concern during this time, but no formal SoE Analyses include mixed effects regressions of QoL scores with SoE as a binary variable Models are adjusted for duration of disease and age at diagnosis and employ random intercepts at clinic and patient level Results: 312 patients were included from Toronto (64%, n=198), Montreal (14%, n=43), Edmonton (7 7%, n=24), Ottawa (5 8%, n=18), Saskatoon (5 4%, n=17), and Kingston (3 8%, n=12) The majority of patients were female (93%, n=291), Caucasian (82%, n=256), and born in Canada (78%, n=242) Mean age was 58 6 years (SD 10 8), mean age at diagnosis was 49 3 years (SD 11 0), mean duration of disease was 9 0 years (SD 7 2), and 6 4% (n=20) had overlap with autoimmune hepatitis Patients had a mean of 1 3 (SD 0 5) repeated measures (maximum 3) 219 patients had measures pre-SoE and 128 had measurements during SoE Estimated mean SF-36 physical component scores were similar before and during the first 3 months of SoE (41 9 vs 40 7, p=0 16), as were SF-36 mental component scores (43 3 vs 43 5, p=0 91) When compared to average Canadian population SF-36 scores, patients with PBC had significantly worse scores before and during SoE (p<0 001 all comparisons) PBC-40 domain scores remained stable, with estimated mean values before and during SoE as follows: Symptoms 13 8 vs 14 2 (p=0 32), Fatigue 24 9 vs 25 0 (p=0 81), Cognitive 10 8 vs 11 1 (p=0 47), Socio-Emotional 25 4 vs 26 2 (p=0 20), Itch 4 7 vs 4 9 (p=0 44) There was a small but statistically significant increase in estimated mean iNRS score, from 2 4 pre-SoE to 3 3 during the first 3 months of SoE (p<0 001) Conclusion: Quality of life scores remained largely stable during the first three months of Canada's SoE SF-36 scores in patients with PBC were significantly worse than Canada's general population Analyses should be updated as Canada's SoE continues
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».