An analysis of mutational signatures in breast cancer among young women
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Notice bibliographique
Résumé
BACKGROUND. Approximately 7% of breast cancer cases are diagnosed among women 40 years of age or younger, and over 40% of all cancer diagnoses in this population are breast cancer. In 1969-2012, there was an increasing incidence of breast cancer among young (≤40 years) Canadian women, and in 1995-2006 there was also an increase in incidence of 3% and 1% among European women 20-29 years and 30-39 years respectively. Younger age is related to later stage at diagnosis, and worse outcomes even when controlling for disease stage and other prognostic features. The most aggressive tumour subtypes, human epidermal growth factor receptor 2 positive and triple-negative breast cancer have a higher prevalence among young women. Clinical and molecular differences between tumours diagnosed at different ages motivates study of differences in patterns of mutations at a genomic level. Mutational signatures are patterns in the type and three-nucleotide neighbourhood of somatic single-nucleotide variants across the exome, which may provide insight into the exposures and processes leading to carcinogenesis. METHODS. Clinical and variant call data for 1098 breast cancer patients was taken from The Cancer Genome Atlas. Cases were separated into young (≤40 years) and old (>40 years) age groups, and the mutational load was found for each. The SomaticSignatures R package was used to determine the mutational spectrum of one young patient. This package will be used to construct mutational spectra for each age group, then decompose them into mutational signatures. RESULTS. There were 91 and 951 patients in the young and old categories respectively. The young group had a median mutational load of 166.5 mutations, slightly less than the median of 198 in the older group. The mutational spectrum showed a high frequency of TCA>TTA and TCT>TTT variants, which is similar to the previously identified Signature 2, and similarly a high frequency of TCA>TGA and TCT>TGT transitions which resembles Signature 13. These two signatures are commonly found in the same tumour, and are thought to be caused by cytidine deaminase activity of AID/APOBEC proteins. CONCLUSIONS. Patterns in a mutational spectrum suggest that Signatures 2 and 13 may be present in at least one young breast cancer tumour, but this approach should be continued to confirm this hypothesis. Further research should be conducted with a larger sample of young breast cancer patients with known exposures to risk factors. *Indicates supervisor
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle