RESEARCH COMMUNICATIONS OF THE 30th ECVIM-CA ONLINE CONGRESS
Notice bibliographique
Résumé
Copper (Cu) influence on chronic hepatitis (CH) have been thoroughly studied in dogs, while a few information on other metals accumulation is currently available. Both Cu and lead (Pb) may cause hepatic injury if their hepatic metabolization is defective or due to oxidative stress mechanisms linked to their presence within hepatocytes, especially for Pb. The aim of the study was to evaluate liver Pb and Cu concentration in dogs with CH. Retrospective evaluation of the Teaching Hospital clinical database was performed searching for dogs with CH and hepatic copper ([Cu]) concentrations, on which lead concentrations ([Pb]) were measured. CH was defined using current ACVIM consensus. [Cu] and [Pb] were evaluated using square wave anodic stripping voltammetry (SWASV; limit of detection (LOD) 10ppm and 6 ppm, respectively). Dogs were divided into two groups based on hepatic [Cu]: Group A <400ppm and Group B 400ppm. [Pb] and [Cu] were correlated using a Spearman correlation test. [Pb] and alanine aminotransferase (ALT) were compared between Group A and Group B using Welch’s t-test and Mann-Whitney U-test, respectively. Thirty-six dogs were screened for eligibility and the final population was composed by 29 dogs, since 7 dogs had [Pb] < LOD and they were censored (6 dogs of Group A and 1 dog of Group B, respectively). The median age was 9 years (range 1-15 years), equally divided between males and females, mainly Labrador Retrievers and Cocker Spaniels (n=3 each), followed by mixed-breed (n=9). Twenty-one dogs (58%) were assigned to Group A, while the remaining 15 dogs were in Group B. [Pb] and [Cu] were strongly positively correlated (p=0.0002; r=0.65). Group A had a mean [Cu] and [Pb] of 236.698 and 4422.3ppm respectively, whereas Group B had a [Cu] and [Pb] of 12891944 and 103.159.8ppm, respectively. Group B showed a significantly higher [Pb] than Group A (p=0.003). ALT was not significantly different between groups (159 vs. 94ppm groups A and B, respectively). \nAlthough further studies are needed to better understand the clinical role of hepatic [Pb], dogs with hepatic abnormal [Cu] may also have higher [Pb] than dogs with normal [Cu], which may be a concomitant storage defect or a direct consequence of Cu hepatic accumulation. However, since few data are available a concomitant oxidative damage caused by increased [Pb] cannot be excluded.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».