Serum EMAP‐II in Young and Older Men During Prolonged Exercise in Temperate and Hot Conditions
Notice bibliographique
Résumé
Recent evidence has revealed a complex interplay between circulating inflammatory cytokines (e.g. TNF‐α, IL‐6) and susceptibility to heat illness, particularly in older adults who demonstrate dysregulation in the inflammatory response. Endothelial monocyte‐activating polypeptide II (EMAP‐II) is a pro‐inflammatory cytokine involved in a number of inflammatory and immune responses. However, the EMAP‐II response, as it relates to exercise‐heat stress is not known. This may be a particularly important cytokine mediating the inflammatory response in older adults, who are known to be at a higher risk for developing heat injury following the strain imposed by prolonged exercise heat stress. Therefore, the purpose of this study was to characterize the EMAP‐II response in young and older men during prolonged exercise in temperate and hot conditions. We evaluated the hypothesis that as observed with other key inflammatory cytokines, end‐exercise serum EMAP‐II concentrations would increase in hot compared to temperate conditions, albeit to a greater extent in young relative to older adults. To achieve this, serum EMAP‐II was measured in 12 young (21 years [SD 3]) and 12 older (59 years [SD 4]) men prior to and following prolonged exercise (180‐min or until volitional fatigue) performed at a metabolic rate of ~200 W/m2 (~3.5 METs) in temperate (21.9°C, 35% relative humidity (RH)) and hot environments (41.4°C, 35% RH) as part of a broader study. Exercise time (min) was compared between groups using a Mann‐Whitney U test. Rectal temperature, averaged over the final 5 min of exercise, and EMAP‐II (quantified via ELISA) at baseline and end‐exercise were analysed using a linear mixed model, with each participant's exercise time considered as a covariate for end‐exercise data. All participants completed 180 min in temperate conditions, although exercise time was reduced to a similar extent in hot conditions in young (median [IQR]; 175 min [108, 180]) vs. older men (180 min [139, 180]; p=0.551). End‐exercise rectal temperature did not differ significantly between groups (p=0.755) but it was higher in hot vs. temperate conditions across groups (mean [SD]; 38.9°C [0.3] vs. 37.5°C [0.3]; p<0.001). Across conditions, EMAP‐II was higher in young vs. older men at baseline (2.18 [0.49] vs. 1.57 [0.48] ng/mL; p=0.003) and end‐exercise (2.32 [0.64] vs. 1.75 [0.48] ng/mL; p=0.009). End‐exercise EMAP‐II was also higher in hot compared to temperate conditions across groups (2.19 [0.53] vs.1.89 [0.70] ng/mL; p=0.003), albeit that increase did not differ significantly between groups (p=0.096). Our findings demonstrate that prolonged exercise in hot, but not temperate conditions, increased EMAP‐II in both young and older men, albeit aging did not significantly influence the magnitude of that increase. However, given aging was associated with an overall reduction in circulating EMAP‐II concentrations, further studies are warranted to assess this response.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».