Features of cognitive impairment in patients with chronic kidney disease stages 3A-5D: biological value of endothelial nitric oxide synthase.
Notice bibliographique
Résumé
THE AIM:a comprehensive assessment of the frequency, severity, and composition of cognitive impairments (CI) in patients with CKD stages 3A-5D, as well as to study the relationship between the levels of endothelial nitric oxide synthase (eNOS) and these impairments. PATIENTS AND METHODS:The study included 80 patients with CKD aged 26 to 79 years (mean age 58.9 ± 1.4 years), among them 43 women (mean age 60.1 ± 1.9 years) and 37 men (mean age 57.4 ± 2.3 years). All patients were divided into 2 groups: group 1 (pre-dialysis) included 40 patients (28 women and 12 men) with CKD 3A-5 (mean age 59.9 ± 2.1 years), group 2 (on dialysis) included 40 patients (18 women and 22 men) with CKD 5D (mean age 58.1 ± 2.1 years). Sarcopenia was verified according to the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP). The presence and severity of CI were determined using the short mental status assessment scale (MMSE) and the Montreal cognitive assessment test (MoCA). To identify endothelial dysfunction, all patients underwent a test with endothelium-dependent vasodilation of the brachial artery, as well as determination of the level of eNOS (ELISA Kit, USA) in serum. RESULTS:The prevalence of sarcopenia in the 1st group was 12.5 %, and in the 2nd group, 42.5 %. The average age of patients with sarcopenia was 66.1 ± 2.1 years. The prevalence of CI according to the MoCA scale in the general cohort was 70 %, while in the 1st group – 67.5 %, in the second – 72.5 %, in the subgroup with sarcopenia – 76.2 %. CIs, determined by the MMSE scale, were on average in 67.5 % of the surveyed, and the quantitative prevalence in the groups was identical, however, the qualitative composition of CIs in the comparative analysis differed in the severity of manifestations. In a comparative assessment of the prevalence of CI (according to the MMSE scale) in patients with sarcopenia, it was found that this indicator was significantly higher than in the subgroup without sarcopenia and amounted to 90.5 % and 59.3 %, respectively. In patients with sarcopenia, the level of eNOS was lower than the mean values compared with the general sample, patients of the 1st group and the subgroup without sarcopenia (0.75 ± 0.1 ng / ml, 0.88 ± 0.1 ng / ml, 1 ± 0.1 ng / ml and 0.92 ± 0.2 ng / ml, respectively (p = 0.02)). According to the results of the test with endothelium-dependent vasodilation, the prevalence of endothelial dysfunction in the total cohort of patients was 48.8 % (in the 1st group – 27.5 %, and in the 2nd group – 70 % (p = 0.001)), in the subgroup of patients with sarcopenia – 57.1 %. CONCLUSION:A high prevalence of CI was found in patients with CKD. The progression of CKD is associated with the formation of endothelial dysfunction and the development of CI. The latter significantly impairs the quality and life expectancy of patients. The main mechanism of their development is increasing endothelial dysfunction, and eNOS plays a key role in this process. Sarcopenia is associated with an increased risk of CI, regardless of the studied population and the criteria for the diagnosis of sarcopenia, and plays an important prognostic value.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».