REGIONAL VARIATION IN FLUID RESERVOIR THICKNESS, OXYGEN TRANSMISSIBILITY AND CORNEAL OEDEMA DURING SCLERAL LENS WEAR
Notice bibliographique
Résumé
Purpose: To determine if regional variation in post lens fluid reservoir thickness (PLFT) during scleral lens wear leads to regional variation in oxygen transmissibility and corneal edema during 4 hours of non-fenestrated scleral lens wear.Methods: About 20 healthy subjects (mean age, 28.8 ± 4.2 years) were fitted with nonfenestrated rotationally symmetric scleral lenses. Anterior segment optical coherence tomography was used to measure cornea thickness before and after lens wear, PLFT 10 minutes and 4 hours after lens application, and scleral lens thickness (with the scleral lens in situ) 4 hours after scleral lens application. These measurements were limited to the central 6 mm and divided into three zones (central, mid-peripheral, and peripheral zones). In the mid-peripheral and peripheral zones, eight principal meridians were measured, generating 17 measurement points in total. Scleral lens thickness and PLFT measurements were corrected for optical distortions by a series of equations. Oxygen transmissibility was calculated by dividing the scleral lens oxygen permeability by the optically-corrected scleral lens thickness, taking into account the oxygen permeability of saline and fluid reservoir thickness.Results: A significant regional variation in PLFT (F = 12.860, P = 0. 012) was observed after 10 minutes of the lens application, PLFT was thickest and thinnest in the inferotemporal and the superonasal region of the peripheral zones( 322.6 ± 161.8 µm and 153.8 ± 96.4 µm, respectively); however, this variation was not statistically significant at 4 hours of scleral lens wear (F = 4.692; P = 0.073). Despite significant regional variation in oxygen transmissibility (F = 48.472; P = 0.001) and relatively low oxygen transmissibility through the scleral lens, induced corneal edema did not vary significantly in different regions (F = 3.346; P = 0.126). In the central corneal region, the induced corneal edema correlated moderately with PLFT (r = 0.468; P = 0.037) and oxygen transmissibility (r = -0.528; P = 0.017). This relationship was insignificant in the peripheral cornea.Conclusion: The inferotemporal peripheral region had the thickest PLFT and least oxygen transmissibility, and the superonasal region had the vice versa. Despite significant variation in PLFT and oxygen transmissibility initially, in healthy corneas, this variation does not seem to induce statistically significant regional variation in corneal edema. Increased central PLFT and decreased oxygen transmissibility moderately correlate with central corneal edema.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».