Rapid Fire Abstract: Congenital heart disease470Impact of training on aortic and cardiac remodelling in a murine model of Marfan syndrome: an echocardiographic study471Pre-intervention morphologic and functional echocardiographic characteristics of 651 neonates with critical left ventricular outflow tract obstruction472Ventricular geometry and function in adult patients with Fontan surgery473Long term functional and myocardial assessment of patients with critical aortic valve stenosis474Late gadolinium enhancement and exercise capacity in adults with Ebstein's anomaly475Exercise echocardiography value in the evaluation of operated aortic coarctation patients476Functional evolution of the right ventricle after pulmonary valve replacement due to significant regurgitation. Implications in the surgical moment decision477Independent predictors of arrhythmias in adult patients with surgically corrected tetralogy of fallot: role of two-dimensional and speckle-tracking echocardiography
Notice bibliographique
Résumé
Purpose: Despite its benefits in preventing cardiovascular diseases in the general population, the aerobic exercise, even of moderate load, is not recommended in patients with the Marfan syndrome (MF).We have previously demonstrated in an animal experimental model the presence of indirect signs of pressure overload in the myocardium of individuals with this syndrome that could be in turn improved with moderate exercise.Our objective was to evaluate the impact of exercise on aortic dilatation and myocardial involvement in an experimental murine model of MF.Methods: We studied 20 wild-type (WT) and 20 Marfan (MF) FBN1C1039G/þ mice (50% female) divided into 4 groups: WT sedentary (10), WT athletes (10), MF sedentary (10) and MF athletes (10).Both WT-and MF-athlete groups underwent 5 months of aerobic training (1 hour/day of running on a treadmill at 20cm/s and 30 slope).Echocardiography was performed at baseline (4 months old) and after 5 months of training and included measurements of aortic root and left atrium size, anterior and posterior wall (AW, PW) thickness, left ventricular diastolic and systolic diameters (LVDD, LVSD), ejection fraction (LVEF) and Tissue Doppler images (TD).The presence of basal septal post-systolic thickening (PST), a marker of myocardial pressure overload, was assessed with both M-mode and TD.Blood pressure was measured at baseline and at the end of the experimental protocol.RESULTS: At baseline, Marfan mice presented with a larger aortic root diameter (1,9 vs 1,48 [mm]; MF vs WT), LV dilation (LVDD, LVSD) but no differences in systolic function (LVEF), thicker ventricular walls (AW, PW) with increased presence of PST (84%) and left atrium dilation.We found no differences in blood pressure between Marfan and WT mice.After 5 months of aerobic training, (i) systolic blood pressure was slightly lower in WT athletes than in MF athletes, (ii) aortic root was significantly smaller in MF athletes than in MF sedentary, (iii) subclinical hemodynamic overload (PST) was blunted in MF athletes (40%) in comparison to their sedentary littermates (71%), which in turn was associated with a decreased LV diastolic dilation and wall thickness in trained MF.CONCLUSIONS: The moderate exercise activity improves cardiovascular echocardiographic parameters in an experimental murine model of MF, suggesting that this type of exercise could even be recommended to human patients.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».