P668. Medical therapy, surgery and hospitalisation rates during the 2- and 3-year follow-up of the 2011 ECCO-EpiCom cohort
Notice bibliographique
Résumé
Background: There are limited data regarding a disease course of newly diagnosed moderate-to-severe ulcerative colitis (UC) in the Asian population.This nationwide hospital inception cohort study in Korea is aimed to reveal the clinical course of patients with newly diagnosed moderate-to-severe ulcerative colitis for 5-year follow-up under usual care.We report our first interim analysis regarding the baseline features of the patients who were enrolled during the first year of study.Methods: We have prospectively enrolled patients with newly diagnosed moderate-to-severe UC at 30 tertiary referral hospitals in Korea since 2014, and collected clinical, epidemiologic, and patientreported outcomes data regarding health-related quality of life.Patients with indeterminate colitis, prior history of colonic resection, or those who participated in interventional clinical trials for UC therapy were excluded.All completed data were transferred via the web to a central database.This study was registered on ClinicalTrials.gov(NCT02229344).Results: Of 131 patients enrolled, 128 who met eligibility criteria were analysed.Of these, 67.2% (86/128) were male, with a male to female ratio of 2.0.The median of age was 34.5 years (14-77); the peak age of onset of symptoms was 20-29 years (28.1%).Further, 5 patients (4.2%) had a first-degree family history of inflammatory bowel disease (exclusively UC), and 1 patient (0.7%) had a history of appendectomy.The disease extent was 12.7% for E1, 39.7% for E2, and 47.6% for E3 according to the Montreal classification.Systemic corticosteroids as an initial treatment were used for 46.1% (59/128) of patients, and their uses were associated with the disease extent (18.8% for E1, 32.0% for E2, and 63.3% for E3, p < 0.001) and the disease activity (43.1% for moderate and 75.0% for severe activity, p = 0.03).With respect to patient-reported outcomes, a high percentage of overall work impairment (48.5%) and daily activity impairment (48.6%) were observed.In addition, a substantial number of patients had clinically significant mood disorder (defined as %score > 11 of the Hospital Anxiety and Depression Scale): anxiety for 11.0% and depression for 13.3%.A clinically significant depression was more common in patients aged over 40 than in younger patients (23.6% vs 5.5%, p = 0.01). Conclusions:The first interim analysis of the MOSAIK cohort shows a male predominance, a peak occurrence in the third decade, and a high proportion of left-sided and extensive colitis.Our data suggest that both assessment of psychosocial distress and adequate psychological support should be integrated into an initial management plan for patients with newly diagnosed moderate-to-severe UC. P668 Medical therapy, surgery and hospitalisation rates during the 2-and 3-year follow-up of the 2011 ECCO-EpiCom cohort
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».