P668. Medical therapy, surgery and hospitalisation rates during the 2- and 3-year follow-up of the 2011 ECCO-EpiCom cohort
Bibliographic record
Abstract
Background: There are limited data regarding a disease course of newly diagnosed moderate-to-severe ulcerative colitis (UC) in the Asian population.This nationwide hospital inception cohort study in Korea is aimed to reveal the clinical course of patients with newly diagnosed moderate-to-severe ulcerative colitis for 5-year follow-up under usual care.We report our first interim analysis regarding the baseline features of the patients who were enrolled during the first year of study.Methods: We have prospectively enrolled patients with newly diagnosed moderate-to-severe UC at 30 tertiary referral hospitals in Korea since 2014, and collected clinical, epidemiologic, and patientreported outcomes data regarding health-related quality of life.Patients with indeterminate colitis, prior history of colonic resection, or those who participated in interventional clinical trials for UC therapy were excluded.All completed data were transferred via the web to a central database.This study was registered on ClinicalTrials.gov(NCT02229344).Results: Of 131 patients enrolled, 128 who met eligibility criteria were analysed.Of these, 67.2% (86/128) were male, with a male to female ratio of 2.0.The median of age was 34.5 years (14-77); the peak age of onset of symptoms was 20-29 years (28.1%).Further, 5 patients (4.2%) had a first-degree family history of inflammatory bowel disease (exclusively UC), and 1 patient (0.7%) had a history of appendectomy.The disease extent was 12.7% for E1, 39.7% for E2, and 47.6% for E3 according to the Montreal classification.Systemic corticosteroids as an initial treatment were used for 46.1% (59/128) of patients, and their uses were associated with the disease extent (18.8% for E1, 32.0% for E2, and 63.3% for E3, p < 0.001) and the disease activity (43.1% for moderate and 75.0% for severe activity, p = 0.03).With respect to patient-reported outcomes, a high percentage of overall work impairment (48.5%) and daily activity impairment (48.6%) were observed.In addition, a substantial number of patients had clinically significant mood disorder (defined as %score > 11 of the Hospital Anxiety and Depression Scale): anxiety for 11.0% and depression for 13.3%.A clinically significant depression was more common in patients aged over 40 than in younger patients (23.6% vs 5.5%, p = 0.01). Conclusions:The first interim analysis of the MOSAIK cohort shows a male predominance, a peak occurrence in the third decade, and a high proportion of left-sided and extensive colitis.Our data suggest that both assessment of psychosocial distress and adequate psychological support should be integrated into an initial management plan for patients with newly diagnosed moderate-to-severe UC. P668 Medical therapy, surgery and hospitalisation rates during the 2-and 3-year follow-up of the 2011 ECCO-EpiCom cohort
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".