Taste Preference Between Ruminant and Industrial Trans Fat in C57BL/6 Mice Measured With the Automated IntelliCage System
Notice bibliographique
Résumé
The objective is to evaluate the taste preference between water, lecithin, R-TFA and I-TFA (TFAs in lecithin at a ratio of 14:86 (w/w)) nanovesicles measured with the automated IntelliCage system in C57BL/6 mice. We hypothesized that the preference for industrially originated trans-fatty acids (elaidic acid (EA trans 18: 1n-9)) and ruminant trans fatty acids (trans-palmitoleic acid (TPA t16:1 n-7)) -is higher than lecithin (control) and/or water. The objective is to evaluate the taste preference between water, lecithin, R-TFA and I-TFA (TFAs in lecithin at a ratio of 14:86 (w/w)) nanovesicles measured with the automated IntelliCage system in C57BL/6 mice. Twenty-four female C57BL/6 mice were divided into 2 groups in two separate IntelliCages where had ad libitum access to food (Teklad global 18% protein extruded (18% fat)). On week 1, both groups had access to only water (control). On week 2, in cage 1 mice received lecithin and EA and in cage 2 mice received lecithin and TPA. In week 3 mice had access to only water. On weeks 4 and 5, mice had access to EA and TPA where the positions of trans fatty acids were interchanged for week 5 compared to week 4. Water also was added to the cages on week 5. Mice weights were measured for each week. Corner preference was recorded by 1- the number of the times a mouse enters a corner (corners visits), 2- crossing a hole to reach the bottles (nose pokes); and 3-the number of licking the bottles (licks). Differences between total number of licks was assessed by t-test. During week 2, mice preferred either EA (7.6 times) in cage 1 or TPA (7.9 times) in cage 2 over lecithin (P < 0.05). During week 4 in cage 1, the mice drank more EA (3.14 times) compared to TPA (P < 0.05). Oppositely during week 4, in cage 2, mice drank more TPA compared to EA (1,2 times, P < 0.05). After corners were switched for fat solutions in week 5, mice drank TPA 2.66 times more than EA (P < 0.05) and 3.5 times more than water (P < 0.05) in cage 1. Equally in cage 2, mice drank EA 1.44 and 4.4 times more than TPA and water (P < 0.05) in week 5. Results showed mice preferred dietary trans fat, either EA and TPA in equal matter over control and drinking water. Further, mice changed their fat preference (EA to TPA and TPA to EA) when the positions of trans fatty acids in corners were switched; therefore, more analysis needs to be done. NSERC, CMDO.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».