← Retour à la cohorte
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola Logan, Shirin Ashraf, Maria Manali, Agnieszka M. Szemiel, Vanessa M. Cowton, Elen Vink, William T. Harvey, Christopher Davis, Patawee Asamaphan, Katherine Smollett, L. Tong, Richard Orton, Joseph Hughes, Poppy Holland, Vanessa Silva, David J. Pascall, Kathryn Puxty, Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew T. G. Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R. Murcia, Arvind H. Patel, Paul Klenerman, Susanna Dunachie, Eleanor Barnes, Anthony Brown, Sandra Adele, Barbara Kronsteiner, Sam M. Murray, Priyanka Abraham, Alexandra Deeks, M. Azim Ansari, Thushan I. de Silva, Lance Turtle, Shona C. Moore, James Austin, Alex Richter, C.J. Duncan, Rebecca Payne, Amy Ash, Cherian Koshy, Beatrix Kele, Teresa Cutiño‐Moguel, Derek Fairley, James P. McKenna, Tanya Curran, Helen Adams, Christophe Fraser, David Bonsall, Helen Fryer, Katrina Lythgoe, Tanya Golubchik, Abigail Murray, Dawn Singleton, Shaun M. Beckwith, Anna Mantzouratou, Magdalena Barrow, Sarah L. Buchan, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, John P.T. Mo, Robert Beer, Safiah Afifi, Sian Morgan, Andrew Mack, Angela Marchbank, Anna Price, Arthur Morriss, Catherine Bresner, Christine Kitchen, Ian Merrick, Joel Southgate, Martyn F. Guest, Owen Jones, Robert J. Munn, Thomas R. Connor, Thomas Whalley, Trudy Workman, William Fuller, Amita Patel, Bindi Patel, Gaia Nebbia, Jonathan Edgeworth, Luke B. Snell, Rahul Batra, Themoula Charalampous, Angela H. Beckett, Ekaterina Shelest, Samuel C. Robson, Anthony P. Underwood, Ben Taylor, Corin Yeats, David M. Aanensen, Khalil Abudahab, Mirko Menegazzo, Amelia Joseph, Gemma Clark, Hannah C. Howson‐Wells, Louise Berry, Manjinder Khakh, Michelle M. Lister, Tim Boswell, Vicki M. Fleming, Christopher W. Holmes, Claire McMurray, Jessica R. Shaw, Julian W. Tang, Karlie Fallon, Mina Odedra, Nicholas J. Willford, Paul Bird, Thomas Helmer, Lesley-Anne Williams, Nicola Sheriff, Veena Raviprakash, Victoria Blakey, Christopher Moore, Fei Sang, Johnny Debebe, Matthew Carlile, Matthew Loose, Nadine Holmes, Victoria Wright, M. Estee Torok, William L. Hamilton, Alessandro M. Carabelli, Andrew Jermy, Beth Blane, Carol Churcher, Catherine Ludden, Dinesh Aggarwal, Elaine Westwick, Ellena Brooks, Georgina M. McManus, Katerina Galai, Kenneth G. C. Smith, Kim S. Smith, MacGregor Cox, Mireille Fragakis, Patrick H. Maxwell, Sarah Judges, Sharon J. Peacock, Theresa Feltwell, Anita Kenyon, Sahar Eldirdiri, Thomas Davis, Joshua F. Taylor, Ngee Keong Tan, Alex E. Zarebski, Bernardo Gutiérrez, Jayna Raghwani, Louis du Plessis, Moritz U. G. Kraemer, Oliver G. Pybus, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Aminu S. Jahun, Ian Goodfellow, Iliana Georgana, Malte L. Pinckert, Myra Hosmillo, Rhys Izuagbe, Yasmin Chaudhry, Felicity Ryan, Hannah Lowe, Samuel Moses, Luke Bedford, James S. Cargill, Warwick Hughes, Jonathan P. Moore, Susanne Stonehouse, Divya Shah, Jack C. D. Lee, Julianne R. Brown, Kathryn Harris, Laura Atkinson, Nathaniel Storey, Moira Spyer, Flavia Flaviani, Adela Alcolea-Medina, Jasveen Sehmi, John Ramble, Natasha Ohemeng-Kumi, Perminder Smith, Beatrice Bertolusso, Claire Thomas, Gabrielle Vernet, Jessica Lynch, Nathan Moore, Nicholas Cortes, Rebecca Williams, Stephen P. Kidd, Lisa J. Levett, Monika Pusok, Paul R. Grant, Stuart A. Kirk, Wendy Chatterton, Li Xu-McCrae, Darren Smith, Gregory R. Young, Matthew Bashton, Katie Kitchman, Kavitha Gajee, Kirstine Eastick, Patrick Lillie, Phillipa Burns, William V. Everson, Alison D. Cox, Alison Holmes, Frances Bolt, James Price, Marcus Pond, Paul Randell, Pinglawathee Madona, Siddharth Mookerjee, Erik Volz, Lily Geidelberg, Manon Ragonnet‐Cronin, Olivia Boyd, Rob Johnson, Cassie F. Pope, Adam A. Witney, Irene M. Monahan, Kenneth G. Laing, Alan McNally, Joanne Stockton, Joshua Quick, Nicholas J. Loman, Radoslaw Poplawski, Samuel M. Nicholls, Will Rowe, Anibolina Castigador, Emily MacNaughton, Kate El Bouzidi, Malur Sudhanva, Temi Lampejo, Rocio T. Martinez Nunez, Cassie Breen, Graciela Sluga, Karen T. Withell, Nicholas W. Machin, Ryan P. George, Shazaad S. Y. Ahmad, David T. Pritchard, Debbie Binns, Nick Wong, Victoria James, Cheryl Williams, Chris J. Illingworth, Christopher Jackson, Daniela De Angelis, Afrida Mukaddas, Alice Broos, Daniel Mair, David L. Robertson, Derek Wright, Emma C. Thomson, Igor Starinskij, Ioulia Tsatsani, James G. Shepherd, Jenna Nichols, Kyriaki Nomikou, Vattipally B. Sreenu, Roy Sanderson, Sarah H. O’Brien, Steven Rushton, Jon Perkins, Rachel Blacow, Abbie Gallagher, Elizabeth Wastnedge, M. McHugh, Rebecca Dewar, Seb Cotton, Lindsay Coupland, Rachael Stanley, Samir Dervisevic, Lewis G. Spurgin, Louise Smith, Clive Graham, Debra Padgett, Edward Barton, Garren Scott, Aidan Cross, Mariyam Mirfenderesky, Emma Swindells, Jane Greenaway, Rebecca Denton-Smith, Robyn Turnbull, Giles Idle, Kevin Cole, Amy Hollis, Andrew Nelson, Clare M. McCann, John Henderson, Matthew Crown, Wen C. Yew, William T. Stanley, Nichola Duckworth, Phillip Clarke, Sarah Walsh, Tim J. Sloan, Kelly Bicknell, Robert Impey, Sarah Wyllie, Scott Elliott, Sharon Glaysher, Declan Bradley, Nicholas F. Killough, Tim Wyatt, Andrew Bosworth, Barry Vipond, Clare Pearson, Elias Allara, Esther Robinson, Hannah M. Pymont, Husam Osman, Peter Muir, Richard Hopes, Stephanie Hutchings, Martin D. Curran, Surendra Parmar, Alicia Thornton, Angie Lackenby, Chloe Bishop, David Bibby, David Lee, Eileen Gallagher, Gavin Dabrera, Ian Harrison, Jonathan Hubb, Katherine A. Twohig, Meera Chand, Nicholas Ellaby, Nikos Manesis, Richard Myers, Steven G. Platt, Tamyo Mbisa, Vicki Chalker, Stefan Rooke, Alec Birchley, Alexander Adams, Alisha Davies, Amy Gaskin, Bree Gatica-Wilcox, Caoimhe McKerr, Catherine Moore, Catryn Williams, Chris Williams, David Heyburn, Elen De Lacy, Ember Hilvers, Fatima Downing, Georgia Pugh, Hannah Jones, Hibo Asad, Jason Coombes, Jessica Hey, Jessica Powell, Joanne Watkins, Johnathan M. Evans, Laia Fina, Laura Gifford, Lauren Gilbert, Lee Graham, Malorie Perry, Mari Morgan, Matthew Bull, Nicole Pacchiarini, Noel Craine, Sally Corden, Sara Kumziene-Summerhayes, Sara Rey, Sarah Taylor, Simon Cottrell, Sophie Jones, Sue Edwards, Tara Annett, Alexander J. Trotter, Alison E. Mather, Alp Aydin, Andrew J. Page, David Baker, Ebenezer Foster-Nyarko, Gemma L. Kay, Justin O’Grady, Leonardo de Oliveira Martins, Lizzie Meadows, Nabil-Fareed Alikhan, Sophie J. Prosolek, Steven Rudder, Thanh Le-Viet, Anna Casey, Liz Ratcliffe, Aditi Singh, Arun Mariappan, Chris Baxter, Clara Radulescu, David Simpson, Deborah Lavin, Fiona Rogan, Julia Miskelly, Marc Fuchs, Miao Tang, Silvia Carvalho, Stephen Bridgett, Timofey Skvortsov, Zoltán Molnár, Newara Ramadan, Bridget Knight, Christopher R. Jones, Cressida Auckland, Helen Morcrette, Jennifer Poyner, Dianne Irish-Tavares, Eric Witele, Jennifer Hart, Tabitha Mahungu, Tanzina Haque, Yann Bourgeois, Christopher Fearn, Kate F. Cook, Katie F. Loveson, Salman Goudarzi, Cariad Evans, David G. Partridge, KATE JOHNSON, Mehmet Yavus, Mohammad Raza, Craig Mower, Paul Baker, Sarah Essex, Stephen Bonner, Leanne J. Murray, Louisa K. Watson, Steven Liggett, Andrew I. Lawton, Ronan A Lyons, Brendan Payne, Gary Eltringham, Jennifer Collins, Sheila Waugh, Shirelle Burton-Fanning, Yusri Taha, Christopher Jeanes, Andrea N. Gomes, Darren R. Murray, Maimuna Kimuli, Donald Dobie, Paula Ashfield, Angus Best, Benita Percival, Emma Moles-Garcia, Fiona Ashford, Jeremy Mirza, Liam Crawford, Megan Mayhew, Nicola Cumley, Oliver Megram, Dan Frampton, Judith Heaney, Matthew Byott, Catherine Houlihan, Charlotte A. Williams, Eleni Nastouli, Helen L. Lowe, John A. Hartley, Judith Breuer, Laurentiu Maftei, Leah Ensell, Marius Cotic, Matteo Mondani, Megan Driscoll, Nadua Bayzid, Rachel Williams, Sunando Roy, Adhyana I. K. Mahanama, Buddhini Samaraweera, Eleri Wilson-Davies, Emanuela Pelosi, Helen Umpleby, Helen Wheeler, Jacqui Prieto, Kordo Saeed, Matthew Harvey, Sarah Jeremiah, Siona Silviera, Stephen Aplin, Thea Sass, Ben Macklin, Dorian Crudgington, Liz A. Sheridan, Benjamin J. Cogger, Cassandra S. Malone, Florence Munemo, Hannah Huckson, Jonathan Lewis, Lisa J. Easton, Manasa Mutingwende, Michelle J. Erkiert, Mohammed O. Hassan-Ibrahim, Nicola J. Chaloner, Olga Podplomyk, Roberto Nicodemi, Sarah Lowdon, Thomas Somassa, Andrew D. Beggs, Andrew R. Hesketh, Colin P. Smith, Giselda Bucca, Chris Ruis, Claire Cormie, Ellen E. Higginson, Jamie Young, Joana Angélica Andrade Dias, Leanne M. Kermack, Mailis Maes, Ravindra K. Gupta, Sophia T. Girgis, Rose K. Davidson, Áine O’Toole, Andrew Rambaut, Ben Jackson, Carlos E. Balcazar, Daniel Maloney, Emily Scher, J. T. McCrone, Kathleen A. Williamson, Michael D. Gallagher, Nathan Medd, Rachel Colquhoun, Thomas D. Stanton, Thomas Williams, Verity Hill, Aaron R. Jeffries, Ben Temperton, Christine Sambles, David J. Studholme, Joanna Warwick-Dugdale, Leigh Jackson, Michelle L. Michelsen, Robin Manley, Stephen L. Michell, Alistair C. Darby, Anita O. Lucaci, Charlotte Nelson, Claudia Wierzbicki, Edith E. Vamos, Hermione J. Webster, Kathryn Jackson, Lucille Rainbow, Margaret Hughes, Mark Whitehead, Matthew Gemmell, Miren Iturriza-Gomara, Richard Eccles, Richard I. Gregory, Sam Haldenby, Steve Paterson, Adrienn Angyal, Alexander J. Keeley, Benjamin H. Foulkes, Benjamin B. Lindsey, Dennis Wang, Hailey Hornsby, Luke R. Green, Manoj Pohare, Marta Gallis, Matthew D. Parker, Max Whiteley, Paige Wolverson, Peijun Zhang, Samantha E. Hansford, Sharon N. Hsu, Stavroula F. Louka, Timothy M. Freeman, Matilde Mori, Emily J. Park, Jack D. Hill, Jayasree Dey, Jonathan K. Ball, Joseph Chappell, C. Patrick McClure, Timothy Byaruhanga, Arezou Fanaie, Geraldine Yaze, Rachel A. Hilson, Amy Trebes, Angie Green, David Buck, George MacIntyre-Cockett, John A. Todd, Andrew R. Bassett, Andrew Whitwham, Cordelia F. Langford, Diana Rajan, Dominic Kwiatkowski, Ewan M. Harrison, Iraad F. Bronner, Jaime M. Tovar-Corona, Jennifier Liddle, Jillian Durham, Katherine L. Bellis, Kevin Lewis, Louise Aigrain, Nicholas Redshaw, Robert M. Davies, Robin J. Moll, Shane McCarthy, Stefanie V. Lensing, Steven Leonard, Ben W. Farr, Charlotte Beaver, Cristina V. Ariani, Danni Weldon, David K. Jackson, Emma Betteridge, Gerry Tonkin‐Hill, Ian Johnston, Inigo Martincorena, James Bonfield, Jeffrey C. Barrett, John Sillitoe, Jon-Paul Keatley, Karen Oliver, Keith James, Lesley Shirley, Liam Prestwood, Luke Foulser, Marina Gourtovaia, Matthew J. Dorman, Michael A. Quail, Michael H. Spencer Chapman, Naomi R. Park, Rich Livett, Roberto Amato, Sally Kay, Scott Goodwin, Scott A. J. Thurston, Shavanthi Rajatileka, Sónia Gonçalves, Stephanie W. Lo, Theo Sanderson, Alasdair Maclean, Emily J. Goldstein, Lynne Ferguson, Rachael Tomb, Jana Catalan, Neil Jones, John Haughney, Massimo Palmarini, Surajit Ray
Notice bibliographique
RevueNature Microbiology · 2022
Typearticle
Langueen
DomaineMedicine
ThématiqueSARS-CoV-2 and COVID-19 Research
Établissements canadiensnon disponible
Organismes subventionnairesInstitute of Infection and ImmunityEngineering and Physical Sciences Research CouncilSheffield Teaching Hospitals NHS Foundation TrustNIHR Oxford Biomedical Research CentreSt George's University Hospitals NHS Foundation TrustOxford University Hospitals NHS Foundation TrustBarts Health NHS TrustGreat Ormond Street Hospital for ChildrenLiverpool University Hospitals NHS Foundation TrustNewcastle upon Tyne Hospitals NHS Foundation TrustCambridge University HospitalsCardiff UniversityUniversity of GlasgowUniversity of NottinghamNational Institute for Health Research Health Protection Research UnitUniversity of OxfordBiotechnology and Biological Sciences Research CouncilWellcome TrustNottingham University Hospitals NHS TrustUniversity College LondonImperial College Healthcare NHS TrustDirectorate for Biological SciencesImperial College LondonBournemouth UniversityUniversity of CambridgeAcademy of Medical SciencesNational Institute for Health and Care ResearchMedical Research CouncilDepartment of Health and Social CareUniversity Hospitals Birmingham NHS Foundation TrustBetsi Cadwaladr University Health BoardGreat Ormond Street Institute of Child HealthNewcastle UniversityAlan Turing InstituteKing's College LondonUniversity Hospitals of Leicester NHS TrustKing's College Hospital NHS Foundation TrustUK Research and InnovationUniversity of PortsmouthNorthumbria University
Mots-clésEndosomeBiologyAntigenicityVirologyIn vitroNeutralizationLipid bilayer fusionViral entryImmune systemReceptorCell biologyGeneticsAntibodyVirus
Résumé
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
score de la tête « metaresearch » (Codex)0,000
score de la tête « metaresearch » (Gemma)0,000
Version: metacan-v3-hybrid-931329e0061cStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Expérimental (laboratoire) · Signal consensuel: Expérimental (laboratoire)
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,001
Score d'incertitude au seuil0,004
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Tête enseignante Opus0,017
Tête enseignante GPT0,295
Écart entre enseignants0,278 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validation
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeExpérimental (laboratoire)
Domainenon disponible
GenreEmpirique
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».
En bref
Citations724
Publié2022
Routes d'admission1
Résumé présentoui