Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease
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Résumé
<h3>Background and Objectives</h3> The glymphatic system is a whole-brain perivascular network, which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal role in amyloid β (Aβ) accumulation. However, its involvement in Alzheimer disease (AD) pathogenesis is not fully understood. Here, we investigated the changes in noninvasive MRI measurements related to the perivascular network in patients with mild cognitive impairment (MCI) and AD. Additionally, we explored the associations of MRI measures with neuropsychological score, PET standardized uptake value ratio (SUVR), and Aβ deposition. <h3>Methods</h3> MRI measures, including perivascular space (PVS) volume fraction (PVSVF), fractional volume of free water in white matter (FW-WM), and index of diffusivity along the perivascular space (ALPS index) of patients with MCI, those with AD, and healthy controls from the Alzheimer9s Disease Neuroimaging Initiative database were compared. MRI measures were also correlated with the levels of CSF biomarkers, PET SUVR, and cognitive score in the combined subcohort of patients with MCI and AD. Statistical analyses were performed with age, sex, years of education, and <i>APOE</i> status as confounding factors. <h3>Results</h3> In total, 36 patients with AD, 44 patients with MCI, and 31 healthy controls were analyzed. Patients with AD had significantly higher total, WM, and basal ganglia PVSVF (Cohen <i>d</i> = 1.15–1.48; <i>p</i> < 0.001) and FW-WM (Cohen <i>d</i> = 0.73; <i>p</i> < 0.05) and a lower ALPS index (Cohen <i>d</i> = 0.63; <i>p</i> < 0.05) than healthy controls. Meanwhile, the MCI group only showed significantly higher total (Cohen <i>d</i> = 0.99; <i>p</i> < 0.05) and WM (Cohen <i>d</i> = 0.91; <i>p</i> < 0.05) PVSVF. Low ALPS index was associated with lower CSF Aβ42 (<i>r</i><sub><i>s</i></sub> = 0.41, <i>p</i><sub><i>fdr</i></sub> = 0.026), FDG-PET uptake (<i>r</i><sub><i>s</i></sub> = 0.54, <i>p</i><sub><i>fdr</i></sub> < 0.001), and worse multiple cognitive domain deficits. High FW-WM was also associated with lower CSF Aβ42 (<i>r</i><sub><i>s</i></sub> = −0.47, <i>p</i><sub><i>fdr</i></sub> = 0.021) and worse cognitive performances. <h3>Discussion</h3> Our study indicates that changes in PVS-related MRI parameters occur in MCI and AD, possibly due to impairment of the glymphatic system. We also report the associations between MRI parameters and Aβ deposition, neuronal change, and cognitive impairment in AD.
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La notice
- Revue
- Neurology
- Thématique
- Cerebrospinal fluid and hydrocephalus
- Domaine
- Neuroscience
- Établissements canadiens
- —
- Organismes subventionnaires
- National Institute on AgingJapan Society for the Promotion of ScienceNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchNational Institutes of HealthGenentechIXICOH. Lundbeck A/SServierEisaiCanon Medical Systems CorporationNorthern California Institute for Research and EducationJapan Agency for Medical Research and DevelopmentPromotion and Mutual Aid Corporation for Private Schools of JapanPfizerBiogenBioClinicaF. Hoffmann-La RocheUniversity of Southern CaliforniaEli Lilly and CompanyU.S. Department of DefenseMeso Scale DiagnosticsAlzheimer's Disease Neuroimaging InitiativeNovartis Pharmaceuticals CorporationBristol-Myers SquibbAlzheimer's AssociationFoundation for the National Institutes of Health
- Mots-clés
- Glymphatic systemCognitionAssociation (psychology)DiseaseCognitive impairmentMedicineAmyloid (mycology)Alzheimer's diseasePathologyPsychologyNeuroscienceCerebrospinal fluidPsychotherapist
- Résumé présent dans OpenAlex
- oui