Parametric Models of Covariance Matrices for Repeated Measures: A Simulation Study on Fit, Error and Statistical Power in Mixed Linear Models
Notice bibliographique
Résumé
The premise in experiments with repeated measures is that observations taken in the same experimental unit are correlated and that correlations decrease proportionally to the increase in the distance between measurements in time or space. Nevertheless, these experiments are often analyzed as if the correlations between the repeated measures were constant or using methods that only consider correlations different, which may impact on the rejection rate of the null hypothesis, and ultimately type I error rate and statistical power. In this context, this study investigated the application of mixed linear models with different assumptions about the covariance matrix in data sets from simulated experiments with repeated measures. 84 scenarios that varied in terms of the covariance matrix pattern (14 structures), number of repeated measurements (4 and 8) and sample size (4, 8 and 12) were evaluated. 10,000 data sets were simulated for each scenario based on a multivariate normal distribution and were subsequently analyzed using mixed linear models. Type I error rate and statistical power for the hypothesis test of the interaction between treatments and repeated measures were estimated as the proportion of p values less than or equal to 0.01 or 0.05 out of a total of 10,000 tests for each scenario. The models were also evaluated for their ability to fit the data using Bayesian Information Criteria (BIC). Thus, the frequency with which the covariance structures were chosen by the selection criteria was computed. Results indicate that the assumption chosen most frequently by the information criteria resulted from the specified covariance structure that corresponded to the empirical covariance structure of the analyzed data sets, particularly for those with larger number of repeated measures and sample sizes. Results also indicate that the use of covariance models that do not recognize heterogeneous correlations between repeated measures can inflate type I error or reduce it to very conservative levels, which may affect the conclusion of agricultural experiments. For a 5% significance level, type I error bias was greater than 2α, while for 1% significance level, bias was over 5α. In addition, the statistical power was reduced when the assumption about the covariance matrix of the data sets did not correspond to the empirical covariance structure, particularly for those data sets with a smaller sample size.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».