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Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
Tae Won Yi, Brendan Smyth, Gian Luca Di Tanna, Clare Arnott, Kathryn Cardoza, Amy Kang, Carol A. Pollock, Rajiv Agarwal, George L. Bakris, David M. Charytan, Dick de Zeeuw, Hiddo J.L. Heerspink, Bruce Neal, David C. Wheeler, Christopher P. Cannon, Hong Zhang, Bernard Zinman, Vlado Perkovic, Adeera Levin, Kenneth W. Mahaffey, Meg Jardine, Barry M. Brenner, Tom Greene, Gary Meininger, Nicole Li, Inna Kolesnyk, Diego Aizenberg, Roberto Pecoits‐Filho, David Z.I. Cherney, Gregorio T. Obrador, Glenn M. Chertow, Tara I. Chang, Carmel M. Hawley, Linong Ji, Takashi Wada, Vivekanand Jha, Soo Kun Lim, Mary Anne Lim-Abrahan, Florence Santos, Dong-Wan Chae, Shang‐Jyh Hwang, Evgueniy Vazelov, Ivan Rychlík, Samy Hadjadj, Vera Krane, László Rosivall, Luca De Nicola, Alexander Dreval, Michał Nowicki, Adalbert Schiller, Larry A. Distiller, José Luis Górriz, Mykola Kolesnyk, David, Caroline P. D. Wheeler, Rodolfo Andrés Ahuad Guerrero, Juan Pablo Albisu, Andres Alvarisqueta, Ines Bartolacci, Mario Alberto Berli, Anselmo P. Bordonava, Pedro Calella, Maria Cecilia Cantero, Luis R Cartasegna, Esteban Cercos, Gabriela Cecilia Coloma, Hugo Colombo, Víctor Commendatore, Jesus Cuadrado, Carlos Alberto Cuneo, Ana María Cusumano, Walter Douthat, Ricardo D. Dran, Eduardo Farias, María Florencia Fernández, Hernan Finkelstein, Guillermo Fragale, Jose Osvaldo Fretes, Néstor H. García, Anibal Gastaldi, Elizabeth Gelersztein, Jorge Archibaldo Glenny, Joaquin Pablo Gonzalez, Patricia del Carmen Gonzalez Colaso, Claudia Goycoa, Gustavo Greloni, Adrián Guinsburg, Sonia Hermida, Luis I. Juncos, Maria Isabel Klyver, Florencia Kraft, Fernando Krynski, Paulina Virginia Lanchiotti, Ricardo Alfonso Leon de la Fuente, Nora Marchetta, Pablo G. Mele, Silvia Nicolai, P. Novoa, Silvia Ines Orio, Fabián Otreras, Alejandra Oviedo, Pablo Raffaele, Jorge Hector Resk, Lucas Rista, Nelson Papini, Jorgelina Sala, Juan Carlos Santos, Lilia Beatriz Schiavi, Horacio Sessa, Tomas Smith Casabella, María Rosa Ulla, María Valdez, Augusto Vallejos, Adriana Villarino, Virginia Esther Visco, Alfredo Wassermann, Cesar Javier Zaidman, N. Wah Cheung, Carolyn Droste, I. W. Fraser, David Johnson, Peak Mann Mah, Kathy Nicholls, David Packham, Joseph Proietto, A. J. Roberts, Simon D. Roger, Venessa Tsang, Roberto Abrão Raduan, Fernando Costa, Celso Amodeo, Luiz Alberto Andreotti Turatti, Rachel Bregman, Fernanda Cristina Camelo Sanches, Luís Henrique Santos Canani, Antônio Roberto Chacra, João Borges, Sérgio Vencio, Roberto Jorge da Silva Franco, Domingos O. d’Avila, Evandro de Souza Portes, Pedro de Souza, Luciane Mônica Deboni, Fadlo Fraige Filho, Bruno Geloneze Neto, Marcus Vinícius Peinado Gomes, Suely Keiko Kohara, Elizete Keitel, José Francisco Kerr Saraiva, Hugo Roberto Kurtz Lisbôa, Fabiana Loss de Carvalho Contieri, Rosângela Milagres, Renan Magalhães Montenegro, Claudia Moreira de Brito, Miguel Nasser Hissa, Ângela Regina Nazario Sabbag, Irene L. Noronha, Daniel Panarotto, Márcio Antônio Pereira, Wladmir Faustino Saporito, Antônio Scafuto Scotton, Tiago Schuch, Roberto Simões de Almeida, Cássio Slompo Ramos, João Soares Felício, Fernando Saldanha Thomé, Jean Carlo Tibes Hachmann, Sérgio Yamada, C Y Hayashida, Tarissa Beatrice Zanata Petry, Maria Teresa Zanella, Viktoria Andreeva, Angelina Angelova, Stefan Dimitrov, Veselka Genadieva, Gabriela Genova-Hristova, Kiril Hristozov, Zdravko Kamenov, Atanas Koundurdjiev, L Lozanov, Viktor Margaritov, Boyan Nonchev, Rangel Rangelov, Alexander Shinkov, Margarita Temelkova, Ekaterina Velichkova, Andrian Yakov, Naresh Aggarwal, Ronnie Aronson, Harpreet S. Bajaj, Guy Chouinard, James Conway, Serge Cournoyer, Gerald DaRoza, Sacha De Serres, François Dubé, Ronald Goldenberg, Anil Gupta, Milan Gupta, Sam Henein, Hasnain Khandwala, Lawrence A. Leiter, François Madore, Alan W. McMahon, Norman Muirhead, Vincent Pichette, Rémi Rabasa‐Lhoret, Andrew Steele, Navdeep Tangri, Ali Torshizi, Vincent Woo, Nadia Zalunardo, María Alicia Fernández Montenegro, Juan Gonzalo Godoy Jorquera, Marcelo Medina Fariña, Victor Saavedra Gajardo, Margarita Véjar, Nan Chen, Qinkai Chen, Shenglian Gan, Yaozhong Kong, Detian Li, Wenge Li, Xuemei Li, Hongli Lin, Jian Liu, Weiping Lu, Mao Hong, Yan Ren, Weihong Song, Jiao Sun, Lin Sun, Ping Tu, Guixia Wang, Jinkui Yang, Aiping Yin, Xueqing Yu, Ming‐Hui Zhao, Hongguang Zheng, J.L. Mendoza, Édgar Arcos, Jorge Avendaño, Jorge Ernesto Andres Diaz Ruiz, Luis Hernando Garcia Ortiz, Alexander Lebrato González, Eric Hernandez Triana, Juan Diego Higuera, Natalia Malaver, Dora I. Molina, Ricardo Rosero, Monica Alexandra Terront Lozano, Luis Alfonso Valderrama Cometa, Álex Valenzuela, Ruben Dario Vargas Alonso, Iván Villegas, Hernan Yupanqui, Dagmar Bartášková, P. Bartoň, Jana Bělobrádková, Lenka Dohnalová, Tomas Drasnar, Richard Ferkl, Katarina Halčiaková, Vera Klokocnikova, Richard Kovar, Jiří Laštůvka, Martin Lukáč, Satu Sinikka Pešičková, Karel Peterka, Jiri Pumprla, F Saudek, Vladimı́r Tesař, Martin Vališ, Pavel Weiner, Stanislav Zemek, É. Alamartine, Sophie Borot, Bertrand Cariou, Bertrand Dussol, Jean‐Pierre Fauvel, Pierre Gourdy, Alexandre Klein, Yannick Le Meur, Alfred Penfornis, Ronan Roussel, Pierre‐Jean Saulnier, Éric Thervet, Philippe Zaoui, Volker Burst, Markus Faghih, Grit Faulmann, Hermann Haller, Reinhold Jerwan‐Keim, Stephan Maxeiner, Björn Paschen, Georg Plaßmann, Ludger Rose, Ronaldo Arturo Gonzalez Orellana, Franklin Paul Haase, Juan Pablo Moreira Diaz, Luis Alberto Ramirez Roca, Jose Antonio Sánchez Arenales, José Vicente Sánchez Polo, Erick Turcios Juarez, Gyongyi Csecsei, Botond Csiky, P. Dános, L. Deák, Mihaly Dudas, Eleonóra Harcsa, Katalin Keltai, Sandor Keresztesi, Krisztián Kis, L. Könyves, Lajos Major, Margit Miléder, Marta Molnar, János Mucsi, Tamás Oroszlán, Ivan Ory, György Paragh, Eva Péterfai, Gizella Petró, Katalin Révész, Robert Takacs, Sandor Vangel, Szilárd Vasas, Marianna Zsom, Oomman Abraham, Raju Sree Bhushan, Dewan Deepak, Fernando M. Edwin, Natarajan Gopalakrishnan, Noble Gracious, Alva Hansraj, Dinesh Kumar Jain, C.B. Keshavamurthy, Dinesh Khullar, Sahay Manisha, Jayameena Peringat, Narayan Prasad, Rao K. Satyanarayana, Reddy Sreedhar, Melemadathil Sreelatha, Bhimavarapu Sudhakar, Ramesh Chandra Vyasam, Riccardo C. Bonadonna, Pietro Castellino, Antonio Ceriello, Luca Chiovato, Salvatore De Cosmo, Giuseppe Derosa, Alberto Di Carlo, Graziano Di Cianni, Giovanni M. Frascà, Giorgio Fuíano, Giovanni Gambaro, Giacomo Garibotto, Carlo Giorda, Fabio Malberti, Marcora Mandreoli, Edoardo Mannucci, Emanuela Orsi, PierMarco Piatti, Domenico Santoro, Ferdinando Carlo Sasso, Gaetano Serviddio, Andréa Stella, Roberto Trevisan, Anna Maria Veronelli, Luca Zanoli, Hitoshi Akiyama, Hiromi Aoki, Akimichi Asano, Tadashi Iitsuka, Shizuo Kajiyama, Susumu Kashine, Toshio Kawada, Takamoto Kodera, Hiroshi Kono, Kazunori Koyama, Yasuro Kumeda, Shozo Miyauchi, Kazuyuki Mizuyama, Tetsuji Niiya, Hiroko Oishi, Satoshi Ota, T Sakakibara, Masahiko Takai, Osamu Tomonaga, Mitsuru Tsujimoto, Masakiyo Wakasugi, Yasushi Wakida, Takayuki Watanabe, Masayo Yamada, Kazuhiro Yanagida, Toshihiko Yanase, Wataru Yumita, Eglė Gaupšienė, Dalia Kozlovienė, Antanas Navickas, Eglė Urbanavičienė, Rohana Abdul Ghani, Norsiah Ali, Mohd Daud Che Yusof, Chye Lee Gan, Mastura Ismail, Wei Yen Kong, Swee Win Lam, Li Yuan Lee, Chek Loong Loh, A.B. Manocha, Kee Sing Ng, Nik Nur Fatnoon Nik Ahmad, Vanassa Ratnasingam, Saiful Shahrizal Shudim, Paranthaman Vengadasalam, Luis David Abraira Munoz, Melchor Alpízar Salazar, Juan Baas Cruz, Mario Burgos Soto, Jose Chevaile Ramos, Alfredo Chew Wong, José Ricardo Correa Rotter, Tonatiu Diaz Escalante, Favio Edmundo Enriquez Sosa, Fernando Flores Lozano, Luis Fernando Flota Cervera, Paul Frenk Barón, Cecilia Garcia Ballesteros, Jose David Gomez Rangel, Luis Enrique Herrera Jimenez, Sergio Saul Irizar Santana, Fernando Jimenez Flores, Hugo Laviada‐Molina, Rosa Isela Luna Ceballos, Belia Martin del Campo Blanco, Guadalupe Morales Franco, Oscar Tarsicio Moreno Loza, Cynthia Mustieles Rocha, Gregorio Obrador Vera, Ricardo Orozco Castellanos, Juan Peralta Calcaneo, Miguel Angel Reyes Rosano, Hiromi Rodriguez Pattzi, Juan Rosas Guzmán, Isabel Erika Rucker Joerg, Sandra Berenice Saavedra Sanchez, Jose Hector Sanchez Mijangos, Pablo Serrano Sanson, Juan Alfredo Tamayo y Orozco, Eloisa Tellez Chavez, Alejandro Valdés Cepeda, Luis Venegas Carrillo, Juan Villagordoa Mesa, Rolando Zamarripa Escobedo, John Baker, P. Noonan, Russell Scott, Robert Walker, Edward Watson, Michael B. Williams, Simon N. Young, Zaynab Abejuela, Jeimeen Agra, Grace Aquitania, Clodoaido Caringal, Rhea Severina Comia, Lalaine Delos Santos, Olivert Gomez, Cecilia Jimeno, Gerry Tan, Marsha Tolentino, Christy Yao, Yvette Ethel Yap, Ma. Dovie Lallaine Ygpuara, Renata Bijata-Bronisz, Lucyna Hotlos, Andrzej Januszewicz, Barbara Kaczmarek, Anna Kamińska, Lech Lazuka, Andrzej Madej, Stanisław Mazur, Dorota Mlodawska-Choluj, Grażyna Orłowska-Kowalik, Grazyna Popenda, Barbara Rewerska, Dariusz Sowiński, Liliana Monica Angelescu, Veronica Anghel, Rodica-Ioana Avram, Mihaela-Magdalena Busegeanu, Adriana Cif, Dana Cosma, Carmen Crișan, Luiza Despina Demian, Ioana Emilia Ferariu, Ildiko Halmagyi, Nicolae Hâncu, Mircea Munteanu, Doru Negru, Adriana Gabriela Onaca, Ligia Petrică, Amorin Remus Popa, Aurelian-Emil Ranetti, Cristian Serafinceanu, Cristina Toarba, Alina Agafyina, О. Л. Барбараш, О Б Барышева, Daniil Chizhov, Vladimir Dobronravov, И. В. Глинкина, Elena Grineva, В. Н. Хирманов, Е. В. Колмакова, Tatiana Koroleva, Liudmila Kvitkova, Viacheslav Marasaev, А. M. Mkrtumyan, Т. В. Моругова, Galina Nagibovich, О А Нагибович, Сергей Владимирович Недогода, Irina Osipova, Т. А. Раскина, Yulia Samoylova, Olga V. Sazonova, Минара Шамхаловна Шамхалова, Е. А. Шутемова, Yuriy Shwartz, Oleg Uriasyev, Sergey N. Vorobyev, Anna Zateyshchikova, Dmitry Zateyshshikov, Tatyana A. Zykova, Slobodan Antić, Miodrag Djordjević, Aleksandra Kendereški, Katarina Lalić, Nebojša Lalić, Vesna Popović-Radinović, Jana Babikova, Olga Benusova, Ingrid Bugáňová, Jan Culak, Andrej Džupina, Jana Dzuponova, Peter Fulop, Adriana Ilavská, Emil Martinka, Zuzana Ochodnicka, Daniel Pella, Iveta Smatanova, Fayzal Ahmed, Aysha Badat, Johannes Breedt, Lawrence Distiller, Vimladhevi Govender, Ravendran Govender, Mukesh C. Joshi, Jaco Jurgens, Gulam Latiff, Landman Lombard, Mohamed Mookadam, Nomangesi Ngcakani, Hendrik Nortje, Helena Oosthuizen, Larisha Pillay-Ramaya, Hans Prozesky, Jeevren Reddy, Paul Rheeder, Mary Seeber, Young Min Cho, In‐Kyung Jeong, Sin Gon Kim, Yeong Hoon Kim, Hyuk‐Sang Kwon, Min Jeong Kwon, Byung‐Wan Lee, Jung Eun Lee, Moon-Kyu Lee, Moonsuk Nam, Kook‐Hwan Oh, Cheol- Young Park, Kun‐Ho Yoon, Pere Alvarez Garcia, Luis Asmarats Mercadal, Clara Barrios, Fernando Cereto Castro, Secundino Cigarrán, Marta Dominguez Lopez, Jesús Egido de los Ríos, Gema Fernández Fresnedo, Antonio Galán Serrano, Isabel Fernández García, Francisco Javier González Martínez, Jose Esteban Jodar Gimeno, Manuel López Mendoza, Tamara Malek Marin, María Antonia Munar Vila, Manuel Muñoz‐Torres, Javier Nieto Iglesias, Jonay Pantoja Perez, Mercè Pérez Vera, Jose Ma Portoles Perez, María Angustias Quesada Simón, Rafael Simo Canonge, Alfonso González, Manel Terns Riera, Francisco J. Tinahones, Mercedes Velo Plaza, Chwen‐Tzuei Chang, Lee‐Ming Chuang, Te‐Lin Hsia, Chang‐Hsun Hsieh, Chih‐Ching Lin, Yung- Chuan Lu, Wayne Huey‐Herng Sheu, Ольга Василівна Барна, Svitlana D. Bilyk, Volodymyr Botsyurko, І. Dudar, I. M. Fushtey, Olga Godlevska, Oleksandr Golovchenko, Olga Gyrina, А. П. Казмирчук, Iuliia Komisarenko, Oleksii Korzh, Н. А. Кравчун, Oleg Legun, Liliya Martynyuk, Yuriy Mostovoy, N.V. Pashkovska, Larysa Pererva, Tetyana Pertseva, Oleksandr Samoylov, Ivan Smirnov, Yevgeniya Svyshchenko, Halyna Tomashkevych, И. И. Топчий, Nadiya Tryshchuk, Vira Tseluyko, Vadym Vizir, М.V. Vlasenkо, Tetiana Zlova, Л.О. Зуб, Salah Abusnana, Mohamed Railey, Kamal Abouglila, Paul Ainsworth, Zishan Ali, Vijayaraman Arutchelvam, Maria Barnard, Srikanth Bellary, T. G. E. Davies, Mark Davies, Simon Davies, Alison Dawson, Mohsen El Kossi, Patrick English, Donald Fraser, Luigi Gnudi, Anthony Gunstone, Timothy J. Hall, Wasim Hanif, Alan Jackson, Andrew D. Johnson, Franklin Joseph, Singhan Krishnan, Mick Kumwenda, Iain C. Macdougall, Paul Nixon, Joseph Paul O’Hare, Sam Philip, Shenaz Ramtoola, Manish Saxena, Davesh Sennik, Godwin Simon, Baldev Singh, Jeffrey W. Stephens, Anna Strzelecka, Rehan Symonds, Wayne Turner, Mona Wahba, John Wakeling, Peter Winocour, Joseph Abdallah, Raied Abdullah, Matthew K. Abramowitz, Idalia Acosta, Joseph Aiello, Laura Akright, Ayim Akyea-Djamson, Rajendran Alappan, Radica Z. Alicic, Amer Al‐Karadsheh, Dale Crawford Allison, Carlos Arauz-Pacheco, Shahabul Arfeen, Ahmed A. Arif, Moogali Arvind, Naveen K. Atray, Ahmed K. Awad, Peggy Barnhill, Elizabeth Barranco, Carlos Barrera, Matthew Beacom, Venkata Behara, Diogo Belo, Rhonda Bentley–Lewis, Ramon Berenguer, Lidia Bermudez, Marializa Bernardo, Mihaela Biscoveanu, Cynthia Bowman-Stroud, Donald Brandon, Osvaldo Brusco, Robert S. Busch, Yamil Canaan, Alicia Chilito, Tom Christensen, Cynthia Christiano, Elena Christofides, Caroucel Chuateco, Kenneth J. Cohen, Robert Cohen, Debbie Cohen-Stein, Charles Cook, Daniel W. Coyne, Nizar Daboul, Riad Darwish, Adarsh Daswani, Kenneth Deck, Cyrus Desouza, Devasmita Dev, Monika Dhillon, Sohan Dua, Frank Eder, Ana Maria Elosegui, Mohamed A. El-Shahawy, John F. Ervin, Alberto Esquenazi, John Evans, Steven Fishbane, Juan P. Frías, Eugenia Galindo-Ramos, Claude Galphin, Adline Ghazi, Enrique González, David M. Gorson, Anupama Gowda, Barbara Greco, Stephen Grubb, Rakesh Gulati, Jamal Hammoud, Stuart Handelsman, Israel Hartman, Kenneth S. Hershon, Daniel Hiser, George Hon, Radu Jacob, Maria Jaime, Aamir Jamal, Charles J. Kaupke, Gerald Keightley, Elizabeth Kern, Rakhi Khanna, Zeid Khitan, Sun H. Kim, Nelson Kopyt, Csaba P. Kövesdy, Gopal Krishna, Jeffrey Kropp, Amrendra Kumar, Jayant Kumar, Neil S. Kumar, Jorge Kusnir, Wendy Lane, Mary Lawrence, Lawrence Lehrner, John Lentz, Dennis J. Levinson, Derek Lewis, Kenneth Liss, Andreas Maddux, Hiralal Maheshwari, Sreedhar Mandayam, Isam Marar, Bhasker Mehta, John P. Middleton, Jorge Mordujovich, Ramon Moreda, Moustafa Sherief Moustafa, Samuel Mujica Trenche, Mohanram Narayanan, Javier Narvarte, Tareq I. Nassar, George E. Newman, Brian Nichol, Philip Nicol, Josier Nisnisan, A. Kaldun Nossuli, Chamberlain I. Obialo, Sarah Olelewe, M. H. Oliver, Andrew Jackson O’Shaughnessy, John Padron, Rohit Pankhaniya, Reginald Parker, Devesh Patel, Gnyandev Patel, Nina Patel, Humberto Pavon, A. Pérez, Carlos A. Pérez, Alan Perlman, Karlton Pettis, Walter Pharr, Andrea Phillips, Raman Purighalla, Luis Quesada-Suarez, Rajiv Ranjan, Sanjeev Rastogi, Jakkidi Reddy, Marc Rendell, Lisa Rich, Michael Robinson, Hector P. Rodríguez, Sylvia E. Rosas, Fadi Saba, Rallabhandi Sankaram, Ravi Sarin, Robert Schreiman, David A. Scott, Mohamed Sekkarie, John Sensenbrenner, Muhammad Shakeel, Michael H. Shanik, Sylvia Shaw, Stephen D. Smith, Richard Solomon, Amy Sprague, Leslie Spry, Pusadee Suchinda, Senan Sultan, Prasanth Surampudi, Sherry Sussman, Anjanette Tan, Antonio Terrelonge, Michael A. Thompson, F. Trespalacios, Bruce S. Trippe, Pilar Trueba, Marcel Twahirwa, John Updegrove, Peter Van Buren, Mark Vannorsdall, Freemu Varghese, Pedro Velasquez‐Mieyer, Sailaja Ventrapragada, Goga Vukotic, Khurram Wadud, Mark Warren, Henry G. Watson, Ronald L. Watts, Daniel Weiner, James Welker, Jean A. Welsh, Shelley Williams, Michelle Zaniewski-Singh
Notice bibliographique
RevueAmerican Journal of Kidney Diseases · 2023
Typearticle
Langueen
DomaineMedicine
ThématiqueDiabetes Treatment and Management
Établissements canadiensLunenfeld-Tanenbaum Research InstituteUniversity of TorontoMount Sinai HospitalUniversity of British Columbia
Organismes subventionnairesSydney Medical SchoolMedical Research CouncilSchool of Medicine, Indiana UniversitySchool of Medicine, Stanford UniversityGeorge Institute for Global HealthNational Health and Medical Research CouncilPeking UniversityYork UniversityUniversitair Medisch Centrum GroningenBrigham and Women's HospitalUniversity College LondonUniversity of TorontoJanssen Research and DevelopmentRijksuniversiteit GroningenUniversity of New South WalesPeking University First HospitalNYU Langone Medical CenterUniversity of Chicago MedicineImperial College London
Mots-clésMedicineCanagliflozinKidney diseaseInternal medicineCreatininePlaceboRenal functionPopulationRandomized controlled trialDiabetes mellitusEndocrinologyType 2 diabetesPathology
Résumé
RATIONALE & OBJECTIVE: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kidney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study. STUDY DESIGN: Secondary analysis of a randomized controlled trial. SETTING & PARTICIPANTS: Participants in the CREDENCE trial. INTERVENTION: Participants were randomly assigned to receive canagliflozin 100mg/d or placebo. OUTCOMES: Primary composite outcome of kidney failure, doubling of serum creatinine concentration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Outcomes were evaluated by age at baseline (<60, 60-69, and≥70 years) and sex in the intention-to-treat population using Cox regression models. RESULTS: The mean age of the cohort was 63.0±9.2 years, and 34% were female. Older age and female sex were independently associated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (a composite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.48-0.82], and 0.89 [0.61-1.29] for ages<60, 60-69, and≥70 years, respectively; P=0.3for interaction) or sexes (HRs, 0.71 [95% CI, 0.54-0.95] and 0.69 [0.56-0.84] in women and men, respectively; P=0.8for interaction). No differences in safety outcomes by age group or sex were observed. LIMITATIONS: This was a post hoc analysis with multiple comparisons. CONCLUSIONS: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants. FUNDING: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical. TRIAL REGISTRATION: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
score de la tête « metaresearch » (Codex)0,029
score de la tête « metaresearch » (Gemma)0,038
Version: metacan-v3-hybrid-931329e0061cStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Méta-analyse · Signal consensuel: aucune
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,029
Score d'incertitude au seuil0,153
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,029 | 0,038 |
| Méta-épidémiologie (sens strict) | 0,003 | 0,001 |
| Méta-épidémiologie (sens large) | 0,007 | 0,010 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,002 |
| Communication savante | 0,002 | 0,002 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,010 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Tête enseignante Opus0,012
Tête enseignante GPT0,302
Écart entre enseignants0,290 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validation
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeMéta-analyse
Domainenon disponible
GenreEmpirique
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».
En bref
Citations29
Publié2023
Routes d'admission2
Résumé présentoui