MP70-01 MANAGEMENT OF THE REFRACTORY NOCTURNAL ENURESIS PATIENT TO DESMOPRESSIN IN A PEDIATRIC POPULATION: DESMOPRESSIN + OXYBUTYNIN VS. DESMOPRESSIN + IMIPRAMINE
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Résumé
You have accessJournal of UrologyCME1 Apr 2023MP70-01 MANAGEMENT OF THE REFRACTORY NOCTURNAL ENURESIS PATIENT TO DESMOPRESSIN IN A PEDIATRIC POPULATION: DESMOPRESSIN + OXYBUTYNIN VS. DESMOPRESSIN + IMIPRAMINE Spencer Shain, Jordan Gitlin, Amelia Pantazis, Ronnie Fine, Mark Horowitz, Steven Friedman, Paul Zelkovic, Lori Dyer, Richard Schlussel, Jamie Freyle, Alexander Fang, Jessica Sommer, and Israel Franco Spencer ShainSpencer Shain More articles by this author , Jordan GitlinJordan Gitlin More articles by this author , Amelia PantazisAmelia Pantazis More articles by this author , Ronnie FineRonnie Fine More articles by this author , Mark HorowitzMark Horowitz More articles by this author , Steven FriedmanSteven Friedman More articles by this author , Paul ZelkovicPaul Zelkovic More articles by this author , Lori DyerLori Dyer More articles by this author , Richard SchlusselRichard Schlussel More articles by this author , Jamie FreyleJamie Freyle More articles by this author , Alexander FangAlexander Fang More articles by this author , Jessica SommerJessica Sommer More articles by this author , and Israel FrancoIsrael Franco More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003338.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Desmopressin (DDAVP) is well accepted as first-line medical therapy for nocturnal enuresis (NE). If DDAVP is ineffective, combination therapy of DDAVP+oxybutynin (Oxy) or DDAVP+imipramine (Imp) has been used. This study assessed the efficacy of adjunct therapy with either Imp or Oxy in the management of NE patients who failed DDAVP treatment. METHODS: A retrospective chart review of our database for patients with NE was performed. All patients who were prescribed DDAVP, Oxy, and Imp over 14 years for NE were included. Two cohorts of patients were examined; group A was treated with DDAVP and Oxy, and group B was treated with DDAVP and Imp. Pretreatment measurement of Vancouver Symptom Score (VSS) was used to compare groups as well as the VSS question “I wet my bed at night” with 4: I wet my bed every night, 3: 4-5 nights per week, 2: 1-2 nights per week, 1: 3-4 nights per month, and 0: never. ICCS criteria for continence success was utilized to determine outcomes. Statistical analysis was performed with SPSS. RESULTS: 2521 patients were identified who were prescribed one of the 3 medications. 72 patients with a mean age of 9.8±2.8 years were identified, of which 48 were male and 24 female. Of these patients, 58 were prescribed both DDAVP and Imp (group B), 23 DDAVP and Oxy (group A), and 9 transitioned from group A to group B. Mean pretreatment VSS showed no difference between the groups. Both groups had minimal drops in wet nights with DDAVP alone. When comparing groups, it was found that group B reduced wet nights significantly more than group A (VSS wet night score 0.7 vs 2.3 respectively). Complete response rate was 68% vs 5% (OR=42.5, p<0.001) (Imp vs Oxy respectively). CONCLUSIONS: A combination of DDAVP and Imp was more effective in reducing wet nights and had a complete response rate that was 42.5 times greater than DDAVP and oxybutynin. Source of Funding: None. © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1003 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Spencer Shain More articles by this author Jordan Gitlin More articles by this author Amelia Pantazis More articles by this author Ronnie Fine More articles by this author Mark Horowitz More articles by this author Steven Friedman More articles by this author Paul Zelkovic More articles by this author Lori Dyer More articles by this author Richard Schlussel More articles by this author Jamie Freyle More articles by this author Alexander Fang More articles by this author Jessica Sommer More articles by this author Israel Franco More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,059 | 0,009 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».