The Brief Case: an Infectious Hazard of Hunting
Notice bibliographique
Résumé
A 38-year-old previously healthy man residing in British Columbia (BC), Canada, presented to medical attention with a 5-day history of fever, chills, night sweats, diffuse myalgias, and arthralgias.He presented no recent travel history.Several months earlier, he had successfully harvested a black bear (Ursus americanus) in BC, and the gathered meat was divided into several pieces and conserved frozen for later consumption.Two days prior to symptom onset, he and four household members ingested meat from the bear which had been thawed and cooked as meatballs.Three other household members also fell ill in the same time frame, but with milder symptoms that did not prompt medical assessment.Several meatballs were subsequently found to have not been thoroughly cooked.Two days after ingestion, the patient noted vague abdominal discomfort and nausea.Eight days after ingestion, he reported intense fever and chills.He also developed mild headache, severe prostration, myalgia in proximal limb muscles, transient abdominal pain, and pink-tinged urine that had resolved at the time of presentation.He denied any vomiting, diarrhea, chest pain, shortness of breath, adenopathy, or rash.The fever lasted for 9 days total, manifesting primarily at night.On examination, his vital signs and physical exam findings were within normal limits.Complete blood cell count was notable for a mildly increased white blood cell count (10.4*10 9 /L; normal range 4.0 to 10.0), and hypereosinophilia (3.3*10 9 /L; normal range 0 to 0.50).Aspartate aminotransferase (AST) (61U/L; normal range 15 to 45), creatine kinase (762U/L; normal range 55 to 170), and C-reactive protein (64.6 mg/L; normal ,10) were all elevated.Bilirubin, creatinine, and international normalized ratio (INR) were within normal range.SARS-CoV-2 RT-PCR respiratory testing was negative, as was HIV screening, and blood cultures at 5 days of incubation.Trichinella serology by commercial indirect enzyme immunoassay (ELISA) targeting the excretory-secretory (ES) antigen performed at the National Reference Center for Parasitology (Montreal, Canada) on a sample drawn 1 week after ingestion of the bear meat was negative.Given the clinical suspicion for Trichinella infection, empirical treatment with mebendazole (400 mg po TID) was initiated on day 12 of illness, for a total of 13 days.The diagnosis of acute trichinellosis was subsequently confirmed based on repeat serological testing performed at the same reference laboratory with the same methodology as initially performed 6 weeks after having consumed the harvested meat which demonstrated a high positive response (optical density [OD] of 3.57; reference high positive cut-off OD $ 1.20).Further microbiological investigations were performed to confirm the source and
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,002 |
| Communication savante | 0,002 | 0,003 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,007 | 0,005 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,002 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».