Correlation between prolonged menopausal hormonotherapy and indicators of vascular and replicative aging in women
Notice bibliographique
Résumé
Objective. To evaluate the impact of prolonged menopausal hormonotherapy (MHT) on women’s biological age indicators. Material and methods. The study included 25 women, who received MHT: 14 of them had timely menopause and 11 of them had premature ovarian insufficiency (POI). The criteria for inclusion of patients with menopause in the study were: age ≥50 years, menopause ≥5 years, MHT ≥5 years. The criteria for inclusion of patients with POI in the study were: age <40 years, POI eligibility, MHT ≥5 years. Control group consisted of women, who had not received MHT, and men: 14 women with timely menopause for more than 5 years, aged ≥50 years, and 11 women with continued menstruation, aged <40 years, 28 men aged ≥50 years and 11 men aged <40 years. The criteria for exclusion were: refusal to participate in the study, oncological disease in active phase or remission less than 5 years, the presence of cardiovascular diseases (except hypertension), morbid obesity. All patients were performed biochemical blood test, pulse wave velocity (PWV) and measured the length of telomere in peripheral mononuclear blood cells by amplification method. Results. The average telomere’s length in women, who had received MHT, was statistically significant less than in women, who had not taken MHT, as well as in men of appropriate age. Statistically significant differences by the telomeres’ length in men and women, who had not received MHT, was not found. Correlation analysis of telomeres’ length with the age of women and menopause duration revealed the significant negative moderate correlations: R= –0.365, p=0.022 and R= –0.319, p=0.047 respectively. PWV, as a marker of artery rigidity, did not differ between groups. The average telomeres’ length in young men was comparable to the telomeres’ length in healthy women and women with POI, who had received MHT. PWV also did not differ between groups of young patients. The average glucose level was lower and the average high density lipoproteins were higher in women taking MHT. The regression analysis based on multiple confounders (age of women and duration of MHT) in the group of postmenopausal women found that the main factor associated with telomeres’ length was MHT. Conclusion. This study demonstrates a direct negative correlation between telomeres’ length and age of patients, and the absence of sex dependence. The protective role of menopausal hormonotherapy in women relating to telomeres’ length and rigidity of magistral arteries has not been proved, but menopausal hormonotherapy is associated with more favorable metabolic profile in women with timely menopause. Longitudinal studies in parallel groups are necessary to determine the role of menopausal hormonotherapy in related to replicative aging.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».