594 SQZ-PBMC-HPV-101: Increased overall survival in a subset of patients with recurrent, locally advanced, or metastatic HPV16<sup>+</sup>tumors treated with cell-based vaccine, SQZ-PBMC-HPV
Notice bibliographique
Résumé
Background Cancer vaccines aim to generate antigen-specific CD8+ T cell responses. However, their efficacy has been hampered by inefficient targeting of delivered antigens to the MHC-I complex. Cell Squeeze® technology delivers target antigens directly into the cytosol of peripheral blood mononuclear cells (PBMC) via temporary cell membrane disruption using a microfluidic chip, which results in increased MHC-I antigen. SQZ-PBMC-HPV is an autologous PBMC cell vaccine targeting HPV16 viral oncoprotein E6 and E7 using the Cell Squeeze platform. Methods SQZ-PBMC-HPV-101 ([NCT04084951][1]) includes HLA-A*02+patients with advanced HPV16 cancers progressing after standard therapy who have an ECOG of 0–1, proper organ function, and RECIST measurable lesion(s). After leukapheresis, the cell product is manufactured in <24 hours with a collection-to-release time of about 1 week. SQZ-PBMC-HPV was given IV q3w without a conditioning regimen. Double antigen priming (DP) was introduced in the last 2 monotherapy cohorts. The response was assessed via RECIST 1.1. Paired biopsies were required at baseline and Day 28. Results Twenty-two patients [head and neck (11), anal (7), and cervical (4)] were dosed in 4 monotherapy cohorts (from 0.5 to 5.0 x10e6/kg [DP]). Treatment was generally well-tolerated. There were no DLTs, Grade (G) >2 related SAEs or related G >3 AEs. Of the eighteen patients with paired biopsies, six had an increase (any increase in CD8 density compared to baseline) in CD8 density (CD8Inc) in the tumor after treatment. These six patients had a median overall survival (mOS) of 607 days (95% CI [314d, 713d]), which was significantly longer than the mOS of patients with a CD8 density decrease (CD8Dec) in the tumor (170 days, 95% CI [54d, 220d], p=0.008). Compared to the 12 CD8Decpatients, CD8Incpatients showed more favorable clinical activitywith 4 out of 6 having stable disease or better while only 2 out of 12 CD8Decpatients had stable disease or better. There were no baseline patient characteristics or on treatment characteristics (e.g. dose level, number of doses received, tumor or peripheral blood biomarkers) that distinguished these groups. Conclusions These findings suggest that a subset of patients treated with SQZ-PBMC-HPV benefit in a manner consistent with the proposed mechanism of action, namely, priming of CD8+ T cells. The sub-set of patients who had an increase in CD8 density within the tumor after treatment showed a 3.5-fold increase in mOS with better control of tumor growth (as measured by clinical response) compared to those without an increase. Acknowledgements We thank the patients, their families, and their caregivers for their time and their willingness to participate in this study. We also thank the investigators and the investigational site staff for their contributions to the study. Ethics Approval The study was performed in accordance with ethical principles that originated in the Declaration of Helsinki consistent with the ICH/GCP and applicable regulatory requirements. The protocol was approved by IRBs/IECs at each center. Patients provided written informed consent to participate. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04084951&atom=%2Fjitc%2F11%2FSuppl_1%2FA676.atom
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».