Efeitos do excesso de lipídios saturados e da curcumina na dieta materna sobre os parâmetros reprodutivos de ratos machos adultos
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Notice bibliographique
Résumé
Disturbances in the intrauterine environment affect fetal metabolism and subsequent offspring's life.Studies show that diets high in fat can have a negative impact on male reproductive parameters, while consumption of curcumin, which is a polyphenol with the potential to induce epigenetic changes and multiple functional activities, can have a positive impact on health.So, this study evaluated whether the maternal consumption of consumption of a lard enriched diet leads to reproductive and metabolic changes in male rat offspring and whether curcumin interferes with this developmental programming.Male Wistar rats (12 weeks of age) were divided according to the mothers' diet and supplementation (gestation and lactation) in Cbalanced diet for rodents (standard diet); Llard enriched diet (31% of lard); Ostandard diet supplemented with corn oil as dilution vehicle (0.1ml/100g body weight, every other day); Cmstandard diet supplemented with corn oil containing curcumin (100mg / kg body weight every other day); and LCmlard-enriched diet supplemented with corn oil/curcumin.Mothers' diet began at week 8, continued until week 12, when they were mated with standard-fed male rats, and continued until weaning (21 days old).Corn oil containing or not curcumin was administered via gavage every other day.Biometric and metabolic parameters of mothers, at weaning, and of offspring were evaluated.For the offspring, in addition to the testicular and epididymal weight, sperm counts, analysis of sperm motility and testicular oxidative stress markers were performed.Data obtained led us to conclude that excessive saturated lipids in the maternal diet during gestation/lactation does not alter sperm production and reserve, nor cause metabolic damage to the offspring, yet impair sperm motility.Dietary supplementation of mothers with small doses of corn oil, during this period, was even more detrimental to the sperm motility of the offspring.Curcumin prevents damage to sperm motility caused on offspring by maternal intake of a lard enriched diet and supplementation with corn oil and this fact may be related to the preservation of lipid metabolism and testicular antioxidant defense.Additionally, we analyzed whether there were changes in the adrenal gland in groups C, L and O.The absolute weight of the adrenals was higher in the group in which the mothers were subjected to the high fat diet, than in C and O groups.There was an increase in the length of area of the three adrenal zones in group L when compared to C and O groups, while O group had increased glomerular zone and decreased reticular zone, in relation to C and L. As there was no variation in the serum level of corticosterone among groups, new analyzes will be necessary to conclude on the effects of the maternal lard enriched diet or the supplementation with corn oil, during pregnancy and lactation, on the adrenal of the male offspring.v v v
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,002 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,002 | 0,001 |
| Intégrité de la recherche | 0,003 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle