Efeitos do excesso de lipídios saturados e da curcumina na dieta materna sobre os parâmetros reprodutivos de ratos machos adultos
Bibliographic record
Abstract
Disturbances in the intrauterine environment affect fetal metabolism and subsequent offspring's life.Studies show that diets high in fat can have a negative impact on male reproductive parameters, while consumption of curcumin, which is a polyphenol with the potential to induce epigenetic changes and multiple functional activities, can have a positive impact on health.So, this study evaluated whether the maternal consumption of consumption of a lard enriched diet leads to reproductive and metabolic changes in male rat offspring and whether curcumin interferes with this developmental programming.Male Wistar rats (12 weeks of age) were divided according to the mothers' diet and supplementation (gestation and lactation) in Cbalanced diet for rodents (standard diet); Llard enriched diet (31% of lard); Ostandard diet supplemented with corn oil as dilution vehicle (0.1ml/100g body weight, every other day); Cmstandard diet supplemented with corn oil containing curcumin (100mg / kg body weight every other day); and LCmlard-enriched diet supplemented with corn oil/curcumin.Mothers' diet began at week 8, continued until week 12, when they were mated with standard-fed male rats, and continued until weaning (21 days old).Corn oil containing or not curcumin was administered via gavage every other day.Biometric and metabolic parameters of mothers, at weaning, and of offspring were evaluated.For the offspring, in addition to the testicular and epididymal weight, sperm counts, analysis of sperm motility and testicular oxidative stress markers were performed.Data obtained led us to conclude that excessive saturated lipids in the maternal diet during gestation/lactation does not alter sperm production and reserve, nor cause metabolic damage to the offspring, yet impair sperm motility.Dietary supplementation of mothers with small doses of corn oil, during this period, was even more detrimental to the sperm motility of the offspring.Curcumin prevents damage to sperm motility caused on offspring by maternal intake of a lard enriched diet and supplementation with corn oil and this fact may be related to the preservation of lipid metabolism and testicular antioxidant defense.Additionally, we analyzed whether there were changes in the adrenal gland in groups C, L and O.The absolute weight of the adrenals was higher in the group in which the mothers were subjected to the high fat diet, than in C and O groups.There was an increase in the length of area of the three adrenal zones in group L when compared to C and O groups, while O group had increased glomerular zone and decreased reticular zone, in relation to C and L. As there was no variation in the serum level of corticosterone among groups, new analyzes will be necessary to conclude on the effects of the maternal lard enriched diet or the supplementation with corn oil, during pregnancy and lactation, on the adrenal of the male offspring.v v v
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".