PC48 EFFECT OF EARLY CHOLESTEROL INTAKE ON CHOLESTEROL BIOSYNTHESIS AND PLASMA LIPIDS
Notice bibliographique
Résumé
Introduction: Early intake of cholesterol and its possible imprinting of later cholesterol metabolism has been studied to understand the influence of infant nutrition on adult cholesterol metabolism and subsequent cardiovascular disease risk. In infants, cholesterol intake relates inversely to endogenous cholesterol fractional synthesis rates (FSR) at 4 months of age. The objective of the present study was to determine whether the level of dietary cholesterol in early life induces changes in FSR and plasma lipids that persist at 18 months. Methods: A prospective, parallel arm, clinical trial was performed in 47 infants followed from their first week of life until 18 months on an unrestricted diet. The first group (n=15) received human milk (HM) until weaned, remaining infants were randomized to receive modified cow-milk formula (MCF) with added cholesterol (n=15), or cow-milk formula (CF, n=17), for 12 months. The cholesterol contents of HM, MCF, and CF were 12, 8, and 4 mg/dl, respectively. FSR and plasma lipids were measured at 4 and 18 months. Results: At 4 months, there was a significant effect of cholesterol intake on FSR (p<0.05) among the three groups. FSR in the HM group (0.034±0.005 pools/day) was lower (p<0.02) than CF (0.052±0.005 pools/day); there was no difference between HM and MCF (0.047±0.005 pools/day), nor between MCF and CF. Infants fed HM (157.5±5.7 mg/dl) and MCF (148.9±6.1 mg/dl) had no difference in plasma total cholesterol (TC), but both were higher (p<0.02) than those fed CF (126.7±5.7 mg/dl). HDL-cholesterol levels were higher (p=0.005) in the MCF group (55.4±2.7 mg/dl) than in the HM (42.3±2.5 mg/dl) and CF (44.6±2.5 mg/dl) groups. LDL-cholesterol levels were higher in the HM group (80.7±4.4 mg/dl) than MCF (60.5±4.6 mg/dl, p=0.0027) and CF (46.4±4.4 mg/dl, p<0.0001); MCF group was also higher (p<0.03) than CF group. There were no differences among groups in VLDL-cholesterol and triglyceride levels. The ratio between TC:HDL-C was lower in MCF (2.76±0.17, p<0.0001) and CF (2.96±0.16, p=0.004) groups than in HM group (3.81±0.16). At 18 months, there were no significant differences among the three groups in any of the aforementioned parameters. Conclusion: While early intake of cholesterol affects FSR and plasma lipids at 4 months, the differences observed between groups do not persist at 18 months. This indicates that there is no imprinting of cholesterol biosynthesis at early life cycle stages by differing dietary levels of cholesterol in infancy.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».