P501 Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: Prevalence and patients’ experience of moderate-to-severe Crohn's disease symptoms in Canada
Notice bibliographique
Résumé
Abstract Background Bowel urgency is known to negatively affect a patient’s quality of life1. The Communicating Needs and Features of IBD Experiences (CONFIDE) study explores patients’ experiences and the impact of moderate-to-severe Crohn's disease (CD) and ulcerative colitis symptoms on their lives in the United States, Europe, Japan, and Canada. The current analyses focus on Canadian patients with moderate-to-severe CD. Methods An online, quantitative, cross-sectional survey was conducted between February and April 2023 in patients with CD. Moderate-to-severe CD was self-reported and defined based on previous treatment, steroid use, and/or hospitalisation. Data on patients' experiences and the impact of CD were descriptively summarised. Results A total of 107 Canadian patients with CD completed the survey (71% male, mean age 45.1 (14.8) years, mean disease duration 10 (10.2) years), of which 79% were receiving advanced therapies at the time of the survey. The top three symptoms currently (in the past month) experienced by patients were diarrhoea (49%), bowel urgency (44%), and loud stomach gurgling/rumbling (40%). Of the patients who had ever experienced bowel urgency (67%), 61% reported experiencing it at least once a week in the past 3 months. Of the patients who had ever experienced bowel urgency-related accidents (48%), 33% reported doing so at least once a week in the past 3 months. Overall, 35% of patients reported wearing diaper/pad/protection at least once a week in the past 3 months due to fear of bowel urgency-related accidents (Table). Bowel urgency (32%), fear of faecal seepage/unnoticed leakage of stool, and increased stool frequency (27% each) were the leading causes for declined participation in work/school (Fig. 1 A). Over one-third of patients declined participation in social events due to bowel urgency (36%) and fear of BU-related accidents (32%; Fig. 1 B). Overall, 37% and 29% of patients declined participation in physical exercise due to bowel urgency and fear of passive incontinence, respectively (Fig. 1 C). Conclusion Bowel urgency was the second-most common symptom among patients with moderate-to-severe CD and the most reported symptom leading to patients declining participation in work/school, social events, and physical exercise. Despite receiving treatment for CD, including advanced therapies, many patients with moderate-to-severe CD continue to report bowel urgency, bowel urgency-related accidents, and the use of diaper/pad/protection. These results underscore the immediate need for a holistic approach to CD management in Canada, focusing on symptom control. Reference: 1. Panaccione, R., et. al., (2023), American Journal of Gastroenterology. 118, S912-S912.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».