P501 Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: Prevalence and patients’ experience of moderate-to-severe Crohn's disease symptoms in Canada
Bibliographic record
Abstract
Abstract Background Bowel urgency is known to negatively affect a patient’s quality of life1. The Communicating Needs and Features of IBD Experiences (CONFIDE) study explores patients’ experiences and the impact of moderate-to-severe Crohn's disease (CD) and ulcerative colitis symptoms on their lives in the United States, Europe, Japan, and Canada. The current analyses focus on Canadian patients with moderate-to-severe CD. Methods An online, quantitative, cross-sectional survey was conducted between February and April 2023 in patients with CD. Moderate-to-severe CD was self-reported and defined based on previous treatment, steroid use, and/or hospitalisation. Data on patients' experiences and the impact of CD were descriptively summarised. Results A total of 107 Canadian patients with CD completed the survey (71% male, mean age 45.1 (14.8) years, mean disease duration 10 (10.2) years), of which 79% were receiving advanced therapies at the time of the survey. The top three symptoms currently (in the past month) experienced by patients were diarrhoea (49%), bowel urgency (44%), and loud stomach gurgling/rumbling (40%). Of the patients who had ever experienced bowel urgency (67%), 61% reported experiencing it at least once a week in the past 3 months. Of the patients who had ever experienced bowel urgency-related accidents (48%), 33% reported doing so at least once a week in the past 3 months. Overall, 35% of patients reported wearing diaper/pad/protection at least once a week in the past 3 months due to fear of bowel urgency-related accidents (Table). Bowel urgency (32%), fear of faecal seepage/unnoticed leakage of stool, and increased stool frequency (27% each) were the leading causes for declined participation in work/school (Fig. 1 A). Over one-third of patients declined participation in social events due to bowel urgency (36%) and fear of BU-related accidents (32%; Fig. 1 B). Overall, 37% and 29% of patients declined participation in physical exercise due to bowel urgency and fear of passive incontinence, respectively (Fig. 1 C). Conclusion Bowel urgency was the second-most common symptom among patients with moderate-to-severe CD and the most reported symptom leading to patients declining participation in work/school, social events, and physical exercise. Despite receiving treatment for CD, including advanced therapies, many patients with moderate-to-severe CD continue to report bowel urgency, bowel urgency-related accidents, and the use of diaper/pad/protection. These results underscore the immediate need for a holistic approach to CD management in Canada, focusing on symptom control. Reference: 1. Panaccione, R., et. al., (2023), American Journal of Gastroenterology. 118, S912-S912.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".