P354 Epidemiological analysis and overall survival of gallbladder malignancies in a developing middle eastern country over 18 years
Notice bibliographique
Résumé
Introduction Despite the rarity of gallbladder cancer, it remains as a leading cause of global health burden, particularly in low resource countries due to the poor overall survival. Therefore, the assessment of the epidemiological features of gallbladder malignancies in middle eastern countries, such as Jordan, is of paramount magnitude in order to enable effective introduction of relevant interventions through careful utilization of resources. Methods Thorough data on 939 male and female individuals of different nationalities residing in Jordan who were diagnosed with gallbladder malignancy from 2000 to 2018 was obtained from the official cancer epidemiological institution in Jordan, the Jordan Cancer Registry. Epidemiological analysis to determine the epidemiological characteristics, crude incidence, and overall survival of gallbladder cancers in Jordan over 18 years was performed. Results A total of 939 individuals with a mean age of 61.6 ± 12.2 years old with a female predominance of 54.4% were included in the analysis. 11.7% of the enrolled individuals were smokers at the time of diagnosis. The gallbladder was the most common tumour site (49%) followed by tumours identified in the ampulla of Vater and extrahepatic bile ducts which were identified in 27.9% and 21.5% of the patients, respectively. Moderately differentiated tumours were the most commonly identified (34.5%), followed by poorly differentiated tumours (15.2%). A worrisome percentage, 22.6%, of the study’s population had widespread disease with distant metastasis at the time of the diagnosis. Whereas only 14.4% of the patients had localized disease at the time of diagnosis. Regional disease was noted in 29.3% of the enrolled individuals. Adenocarcinoma was the most prevalent tumour morphology (64.4%), followed by cholangiocarcinoma which was identified in 15.7% of the patients. The overall survival was noted to be 79.7%, 71.8%, 71%, 70.9%, and 70.8% at 1-year, 2-year, 3-year, 4-year, and 5-year interval, respectively. In terms of crude incidence, a statistically insignificant incline has been noted over 18 years with a crude incidence estimated effect of 0.015. Conclusions The majority of gallbladder malignancies in Jordan over a time period of 18 years were identified once the tumour has spread either, regionally or distantly. The overall survival however appears to be promising and thus mandates comprehensive investigation to determine the driving factors behind it.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».