P354 Epidemiological analysis and overall survival of gallbladder malignancies in a developing middle eastern country over 18 years
Bibliographic record
Abstract
<h3>Introduction</h3> Despite the rarity of gallbladder cancer, it remains as a leading cause of global health burden, particularly in low resource countries due to the poor overall survival. Therefore, the assessment of the epidemiological features of gallbladder malignancies in middle eastern countries, such as Jordan, is of paramount magnitude in order to enable effective introduction of relevant interventions through careful utilization of resources. <h3>Methods</h3> Thorough data on 939 male and female individuals of different nationalities residing in Jordan who were diagnosed with gallbladder malignancy from 2000 to 2018 was obtained from the official cancer epidemiological institution in Jordan, the Jordan Cancer Registry. Epidemiological analysis to determine the epidemiological characteristics, crude incidence, and overall survival of gallbladder cancers in Jordan over 18 years was performed. <h3>Results</h3> A total of 939 individuals with a mean age of 61.6 ± 12.2 years old with a female predominance of 54.4% were included in the analysis. 11.7% of the enrolled individuals were smokers at the time of diagnosis. The gallbladder was the most common tumour site (49%) followed by tumours identified in the ampulla of Vater and extrahepatic bile ducts which were identified in 27.9% and 21.5% of the patients, respectively. Moderately differentiated tumours were the most commonly identified (34.5%), followed by poorly differentiated tumours (15.2%). A worrisome percentage, 22.6%, of the study’s population had widespread disease with distant metastasis at the time of the diagnosis. Whereas only 14.4% of the patients had localized disease at the time of diagnosis. Regional disease was noted in 29.3% of the enrolled individuals. Adenocarcinoma was the most prevalent tumour morphology (64.4%), followed by cholangiocarcinoma which was identified in 15.7% of the patients. The overall survival was noted to be 79.7%, 71.8%, 71%, 70.9%, and 70.8% at 1-year, 2-year, 3-year, 4-year, and 5-year interval, respectively. In terms of crude incidence, a statistically insignificant incline has been noted over 18 years with a crude incidence estimated effect of 0.015. <h3>Conclusions</h3> The majority of gallbladder malignancies in Jordan over a time period of 18 years were identified once the tumour has spread either, regionally or distantly. The overall survival however appears to be promising and thus mandates comprehensive investigation to determine the driving factors behind it.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".