Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology
Notice bibliographique
Résumé
BACKGROUND: Preterm birth is associated with significant risks for long-term impairments in brain structure and cognitive functions (1). At the microscopic level, the transient inflammatory and hypoxic-ischemic events occurring during premature birth disrupt the development of subplate neurons and pre-oligodendrocytes, both of which play a crucial role in the establishment of thalamo-cortical connections and the maturation of the claustrum (2,3). Altered thalamo-cortical connectivity and claustrum microstructure have previously been reported in preterm-born infants (4,5). This study combines findings from two investigations aiming at exploring the long-term consequences of prematurity on these subplate and pre-oligodendrocyte-dependent systems (6). \nMETHODOLOGY: Thalamo-cortical (TC) and claustro-cortical (CC) connections were reconstructed from diffusion-weighted imaging data using probabilistic tractography. Streamlines were generated between bilateral thalami or claustra and cortical regions of interest (see Figure 1A and 2A-C). Connection probability was chosen as metric of TC structural connectivity in a sample of 67 very preterm (PT) and 70 full-term (FT) born adults while CC connectivity was measured as connection density in 65 PT and 81 FT born adults of the BLS at 26 years. In both studies, cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale. Additionally, a verbal comprehension subtest score was computed in the first study. Neonatal medical complications were assessed using a standardized optimality scoring system (OPTI). Differences between groups and their associations with prematurity or cognitive variables were performed via ANCOVAs and linear regressions (study 1) or Pearson correlations (study 2) respectively. \nRESULTS: Findings revealed increased connectivity between the left thalamus and left prefrontal cortex in very preterm-born adults, which was associated with both lower birth weight and a lower verbal comprehension score (Figure 1A-B). Furthermore, decreased connectivity between bilateral thalami and temporal cortices in PT born adults positively correlated with the duration of ventilation during the neonatal period (Figure 1A). Finally, lower connectivity between bilateral claustra and parieto-occipital cortices in PT born adults was associated with lower gestational age, birth weight and a higher degree of neonatal complications (Figure 3A-B). Lower left claustro-occipital connectivity was also associated with lower IQ. \n \nCONCLUSION: Together, these findings suggest that prematurity has a lasting impact on cortico-subcortical white matter connectivity, particularly in subplate/pre-oligodendrocytes-derived systems. Furthermore, these alterations are linked to the degree of prematurity and have implications for the persistence of cognitive impairments into adulthood.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,002 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».