The Role of Endogenous Circular RNAs in Glioblastoma Treatment Resistance: A Literature Review
Notice bibliographique
Résumé
Introduction: Glioblastomas are a high-grade primary brain cancer of astrocytes, a glial cell. The average survival upon diagnosis is 15 months. Researchers have been continuously attempting to develop new drugs and therapies that would exhibit greater efficiency against this cancer. However, tumor resistance is often observed in glioblastomas. Circular RNA is a relatively novel finding of non-coding RNA that is highly stable compared to linear RNA. Recent studies have found a variation in circular RNA expression levels in resistant versus non-resistant cancer cell lines. Thus, researchers have been exploring this endogenous entity to understand the role it may play in chemo- and radioresistant glioblastomas. Methods: A comprehensive look into the most recent findings on this topic was done using Google Scholar and PubMed search engines. Key words used include “circRNA,” “glioblastoma,” and “chemo- and radio-resistance”. This review mainly stems from primary research published between 2017 and 2024. Results: Only a few specific circular RNAs have been found to be implicated in chemoresistance. Research has focused on understanding resistance to temozolomide. However, variation in certain circular RNA expression has also been noted in cisplatin and histone deacytlase inhibitor therapies for glioblastoma treatment. These circular RNAs inhibit the cytotoxic effects of chemotherapeutics primarily though microRNA sponging. Additionally, similar results were found in radioresistant glioblastoma tumors, whereby specific circular RNAs block apoptosis by altering various protein mechanisms through microRNA sponging and inhibiting translocation. Discussion: Developing methods that inhibit this tumor’s ability to resist otherwise effective therapies may be an ideal method of treatment. Many studies have attempted to modify cellular pathways to facilitate apoptosis of cancer cells. However, due to complex interactions and possible off-target effects, these methods are inefficient. Circular RNAs may serve as improved therapeutic targets due to their tissue specificity and increased stability. Conclusion: The newly identified circular RNAs involved in glioblastoma therapy resistance may be used to increase cancer cell susceptibility to treatments. Knock-out and overexpression analysis indicate these molecules to be sufficient in altering resistance abilities of these cells. Highly specific targeting techniques may therefore be a viable solution for chemo- and radioresistance.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,000 | 0,003 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».