Intestinal atresia in a 2‐day‐old puppy
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Résumé
A 2-day-old male entire labrador cross golden retriever puppy was presented bloated, cold and minimally responsive. The puppy was euthanased on welfare grounds, and a postmortem examination identified a segmental intestinal atresia of the small intestine, with rupture of the dilated intestine cranial to the atresia with meconium found within the peritoneal cavity (Figure 1). The macroscopic findings were consistent with intestinal atresia type II (Figure 2). The histopathological investigation of the atretic segment identified a primitive non-recanalised intestinal structure, with the lumen obliterated by epithelium and stroma (Figure 1, inset). The histopathology was consistent with intestinal atresia type II. Intestinal atresia, an uncommon congenital disease of domestic animals, is most likely secondary to segmental ischaemia during early fetal life.1, 2 Atresia ilei is most prevalent in calves and rare in foals, lambs, piglets and pups. It is unlikely to be heritable in many species; however, a genetic basis has been reported in calves.1 In human medicine, familial cases of intestinal atresia have been reported, but the majority of cases occur sporadically. These cases share the same pathogenesis as in domestic mammals occurring due to a vascular accident involving the mesenteric blood supply in utero.3 Shauna Hilton carried out the postmortem examination, histopathology and drafted the manuscript. Holly Cuttiford created the hand-drawn diagram and carried out the postmortem examination. Bethany Wong and Haydn Stanney performed the postmortem examination and contributed to the macroscopic report. Carlo Bianco carried out the postmortem examination and co-drafted the manuscript. The authors thank Emma Pritchard for processing the histopathology. The authors declare they have no conflicts of interest. The macroscopic postmortem examination was performed as part of the routine commercial diagnostic service at the School of Veterinary Medicine and Science of the University of Nottingham, and no further funding was received. The puppy was submitted for a diagnostic postmortem examination following euthanasia. Consent for publication was agreed by the submitting institution. Considering Figure 1 what's the likely diagnosis? Small intestine: severe acute diffuse necrotising and haemorrhagic enteritis Small intestine: segmental atresia Small intestine: volvulus Small intestine: hernia Small intestine: segmental atresia The necrotising and haemorrhagic enteritis do not typically display marked variation in the diameter of the affected segments and the serosa appears dark red to black. The volvulus is a twist of the mesenteric root with infarction and dilation of a segment of the ischaemic intestine. A hernia is a displacement of an organ through a congenital or acquired pathological opening.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle