S14 Burden and Impact of Abdominal Pain in Moderate to Severe Crohn’s Disease and Ulcerative Colitis: Results from the Communicating Needs and Features of IBD Experiences (CONFIDE) Survey
Notice bibliographique
Résumé
Background: Abdominal pain (AP) is a common symptom of Crohn’s disease (CD) and ulcerative colitis (UC), affecting up to 70% of patients. The Communicating Needs and Features of IBD Experiences (CONFIDE) survey explored the experience and impact of CD and UC-related symptoms among patients in the United States (US), Europe (France, Germany, Italy, Spain, and UK), and Japan. We investigated the impact of AP among US and European patients with CD or UC. Methods: Online, quantitative, cross-sectional surveys were conducted among patients with moderate to severe CD or UC (defined by previous treatment, steroid use, and/or hospitalization). Patients were asked about the impact and severity of AP (‘AP before bowel movement (BM)’ and ‘persistent AP’); patients recorded AP severity over the past 3 days using the 11-point AP Numeric Rating Scale (NRS; 0=no pain; 10=worst possible pain). Data are presented as descriptive statistics. Results: Surveys were completed by 215 US (54.9% male, mean age: 40.9 years) and 547 European (55.4% male, 38.0 years) patients with CD and 200 US (61.5% male, 40.4 years) and 556 European (57.4% male, 38.9 years) patients with UC. More than 20% of all patients reported currently experiencing (in the past month) ‘AP before BM’ (CD, US: 34.9%, Europe: 25.0%; UC, US: 31.0%, Europe: 20.7%) and/or ‘persistent AP’ (CD, US: 22.3%, Europe: 20.3%; UC, US: 22.0%, Europe: 20.1%). Overall, 9.8% US and 11.0% European patients with CD and 12.0% US and 5.6% European patients with UC reported currently experiencing both symptoms. Among patients who had ever experienced ‘AP before BM’ (CD, US: 48.8%, Europe: 41.3%; UC, US: 45.5%, Europe: 32.0%) or ‘persistent AP’ (CD, US: 43.7%, Europe: 36.6%; UC, US: 38.0%, Europe: 31.3%), more than one-third ranked them among top 5 symptoms with greatest impact on them (‘AP before BM’: CD, US: 53.3%, Europe: 34.1%; UC, US: 49.5%, Europe: 44.4%; ‘persistent AP’: CD, US: 54.3%, Europe: 47.0%; UC, US: 53.9%, Europe: 66.1%). Additionally, of those who ever experienced either symptom, most reported experiencing them at least once a week during the past 3 months (‘AP before BM’: CD, US: 65.7%, Europe: 56.2%; UC, US: 70.3%, Europe: 60.7%; ‘persistent AP’: CD, US: 59.6%, Europe: 60.0%; UC, US: 67.1%, Europe: 59.2%). Mean (SD) AP NRS scores in the overall population were 6.4 (2.7) and 5.7 (2.7) for US and European patients with CD, and 6.4 (2.4) and 6.1 (2.3) for US and European patients with UC, respectively. Approximately 20% of all patients reported ‘AP before BM’ and/or ‘persistent AP’ as a reason for declining participation in work/school, social activities, and sports/physical exercise in the past 3 months. Among patients who reported decreased sexual activity due to CD or UC (CD, US: n=148, Europe: n=305; UC, US: n=126, Europe: n=292), 22.6–38.5% cited disease-related AP as the reason and 14.0–27.8% indicated that their AP worsened during intercourse. Conclusions: Abdominal pain, both persistent and before bowel movement, is a frequent and severe symptom among patients with moderate to severe CD or UC. While literature more often links abdominal pain to CD, our findings indicated a similar impact of abdominal pain among patients with CD and UC, across US and European populations. Assessing and addressing abdominal pain in clinical practice is crucial for effective management of both CD and UC.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».