Self-Reported Burden and Health-Related Quality of Life in Acute Kidney Injury Survivors Compared with Patients with Advanced CKD
Notice bibliographique
Résumé
Key Points Patients recently discharged after a severe AKI episode have a low health-related quality of life. This self-reported quality of life is comparable with that of people living with advanced CKD. Background Survivors of severe AKI are at risk of increased morbidity. There are limited data of the quality of life (QOL) of patients who recently have had an AKI episode. The purpose of this study was to explore the health-related QOL of severe AKI survivors when compared with patients living with advanced CKD. Methods A prospective observational cohort study of severe AKI survivors who attended follow-up in a specialized post-AKI clinic was compared with a cohort of patients with advanced stage 4 or 5 CKD followed in a dedicated nephrology clinic. Self-reported health-related QOL was determined with the Treatment Burden Questionnaire (TBQ) and compared between both groups. Results A total of 100 participants were included in this analysis. As opposed to participants with CKD, AKI survivors were younger (median age: 63 [52–72] versus 72 [62–79] years) and had lower comorbidities (median Charlson index: 5 [2–7] versus 8 [6–9]) and higher eGFR at follow-up (median: 60 [40–82] versus 15 [12–20]). The overall QOL reported by AKI survivors was not statistically different from participants with advanced CKD (median TBQ score: 19.0 [6.5–43.8] versus 25 [12.8–43.0]), P = 0.45). The only domain where a significant difference was observed between the two cohorts was dietary restrictions ( P = 0.037). A negative correlation between age and TBQ score was observed (Spearman's rank: −0.23 [ P = 0.02]), especially in participants with CKD (−0.51 [ P = 0.001]), meaning older participants reported a lower effect on health-related QOL, and between eGFR and TBQ (−0.20 [ P = 0.049]), meaning participants with lower eGFR reported lower health-related QOL. No correlation was observed for hospital length of stay, burden of medication, or follow-up duration since hospital discharge. Conclusions This study showed that health-related QOL of patients recently discharged after a severe AKI episode is comparable with the low QOL reported by patients living with advanced CKD. How to integrate that information into clinical practice when offering post-AKI care requires further research.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».