A228 PSYCHOSOCIAL FACTORS IN ADULTHOOD AND RISK OF INFLAMMATORY BOWEL DISEASE
Notice bibliographique
Résumé
Abstract Background Few studies have assessed the possible etiological role of psychosocial factors on inflammatory bowel disease (IBD). We have previously reported that some childhood psychosocial factors were associated with increased odds of IBD in adulthood. Aims The aim of this study was to estimate the associations between self-reported psychosocial factors first experienced in adulthood and occurrence of IBD later in life. Methods This matched case-control study was nested within a cohort of individuals born in Quebec in 1970-1974. Cases were identified with validated algorithms based on health services from 1983 to 2014; their date of diagnosis was based on their first health service (index date). Only cases diagnosed with Crohn’s disease (CD) (n = 1041) or ulcerative colitis (UC) (n = 511) at ≥18 years were included. Each case was individually matched with a control based on sex and birth year. Cases and controls completed a questionnaire documenting sociodemographic, lifestyle, and psychosocial factors up to the age corresponding to the index date. The psychosocial factors (n = 17) experienced in adulthood related to work (interruption, changes, problems), difficulties (academic, financial), judicial problems, marriage or union, divorce or separation (parents’/own), familial conflict, birth of a child, death (spouse or child/other loved one), depression, anxiety, accident, violence or abuse. Potential confounders were based on a priori knowledge. Conditional logistic regression was applied to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for each psychosocial factor, for CD and UC separately. Multiple imputations were used to address missing data. Results Adjusting for potential confounders, the odds of CD were higher among those who had experienced changes in the workplace (OR: 1.58; 95% CI: 0.96-2.61), marriage (OR: 1.32; 95% CI: 1.06–1.64), divorce or separation (OR: 1.75; 95% CI: 1.19-2.58), death of spouse or child (OR: 3.21; 95% CI: 1.12-9.19), anxiety (OR: 2.17; 95% CI: 1.25-3.78), and accident (OR: 1.72; 95% CI: 1.09-2.73). The odds of UC were higher among those who had experienced problems at work (OR: 2.00; 95% CI: 1.03-3.87) and anxiety (OR: 1.75; 95% CI: 0.93 - 3.32) and lower among those exposed to changes in the workplace (OR: 0.48; 95% CI: 0.23-1.00). The other psychosocial factors were not associated with either CD or UC. Conclusions Several psychosocial factors, first experienced in adulthood, were associated with increased odds of CD or UC later in life, whereas only one, changes in the workplace was associated with decreased odds of UC. Further research should consider the self-reported subjective impact of these psychosocial factors. Funding Agencies CIHRCanada Foundation for Innovation & the Québec Ministry of Education, Leisure and Sports (#12532), Fonds de recherche du Québec-Santé (FRQS, #16227), Multiple Sclerosis Society of Canada (#2435), Institut de la statistique du Québec
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».