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Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial
Amy Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia S. Field, Philip A. Barber, Philip Choi, Brian Buck, Timothy Kleinig, Carlos A. Molina, Bruce Campbell, Ramana Appireddy, Keith W. Muir, Michael D. Hill, Shelagh B. Coutts, Marina Salluzzi, Nicole Blenkin, Ashley Dueck, Craig Doram, Qiao Zhang, Carol Kenney, Charlotte Zerna, Karla J. Ryckborst, Shelly Bohn, Dar Dowlatshahi, Robert J. Hard, David M. Kent, Renee Martin, William Whiteley, Quinten Collier, Frances Taylor, Brendan Cord Lethebe, PA Barber, C Kenney, Anitha Jambula, Karen Sage, Loren Toussaint, Sushma Save, Jungwha Lee, Nihay Laham-Karam, Assem A. Sultan, Aimen Moussaddy, Akshay Deepak, A Sitaram, Andrew M. Demchuk, Andrew Lockey, Andrew Micielli, Ankur Wadhwa, Babawale Arabambi, Bijoy K. Menon, B Graham, Clement C. Tham, Chrysi Bogiatzi, Dolar Doshi, Debabrata Chakraborty, Do Young Kim, Denise Vasquez, Dolly Singh, Darren Tse, Earl C. Harrison, Eric E. Smith, Erika Teleg, Evgenia Klourfeld, Gary Klein, Ivy Sebastian, J. Grimley Evans, Janka Hegedus, Julie Kromm, Katie Lin, Katrina Hannah D. Ignacio, Khosrow Ghavami, Mohammed Ismail, Margaret Moores, Marie-Andrée Panzini, Martha Marko, Matthew Boyko, Mohammed Almekhlafi, Nancy Newcommon, Nicholar Maraj, Nishita Singh, Oje Imoukhuede, Ondřej Volný, Peter K. Stys, P Couillard, Piyush Ojha, PrasannaVenkatesan Eswaradass, RA Joundi, Rajesh Kumar Singh, R.M. Asuncion, Ryan T. Muir, Subhalaxmi Dey, Sana Mansoor, Sanchea Wasyliw, S Nagendra, Shiyu Hu, Shorog Althubait, Shuo Chen, Simerpreet Bal, Stephen van Gaal, Sanne A. E. Peters, Sucharita Ray, S. K. Chaturvedi, Suresh Subramaniam, Vivian Fu, Karina Villaluna, G. L. Maclean, Princess King-Azote, Chaoyang Ma, Alyson Plecash, Colleen Murphy, Laura Wilson, Oscar Benavente, P. Teal, Samuel Yip, Samuel J. Mann, B. Dewar, Michele Demetroff, Reham Shamloul, Rebeccah Beardshaw, Susan B. Roberts, Dylan Blaquiere, Grant Stotts, Michel Shamy, Olena Bereznyakova, Robert Fahed, Walid Alesefir, Marie‐Christine Camden, Suzy Lavoie, Annette Haché, Karine Collard, Ariane Mackey, Stéphanie Gosselin-Lefebvre, Steve Verreault, Jennifer Mandzia, Beth Beauchamp, Lindsay Lambourn, Alexander V. Khaw, L. Mai, Luciano A. Sposato, María Bres Bullrich, R. Azarpazhooh, Sebastián Fridman, Arunima Kapoor, Angela Southwell, Edoardo Bardi, Idris Fatakdawala, Maneesha Kamra, Kaitlynn M. Lopes, Najla Popel, Vanessa Norouzi, Aihua Liu, Ann-Marie Liddy, Bismah Ghoari, Colin P. Hawkes, C.A. Enriquez, David J. Gladstone, Herbert Alejandro Manosalva Alzate, Houman Khosravani, Julia Hopyan, Kousik Sivakumar, Mia Son, Mark I. Boulos, M.A. Hamind, Richard H. Swartz, Robert Murphy, Stephanie Reiter, Thomas Fitzpatrick, Virendra Bhandari, Andrew M. Penn, J Good, Melanie Penn, Mary D. Naylor, Steven A. Frost, Leanne K. Casaubon, Anne Cayley, Farhana Akthar, David Williams, L Kalman, Lisa Crellin, Rebecca Wiegner, Sarman Singh, Thomas G. Stewart, Wing Kin To, Aleksandra Pikula, Cheryl Jaigobin, Federico Carpani, Frank L. Silver, Heidi Janssen, Joanna D. Schaafsma, Miguel Del Campo, Mohammed A. Alskaini, Phavalan Rajendram, Paige Fairall, Bonny Granfield, Dorothy H. Crawford, Juline Jabs, Laura White, Leka Sivakumar, Lori Piquette, Thanh N. Nguyen, Alireza Nomani, Aaron Wagner, A Alrohimi, Adeel A. Butt, Alicia D’Souza, Bikram Prasad Gajurel, Chetan Vekhande, Hemant Kamble, Hayrapet Kalashyan, Kenneth Butcher, María Jesús Lloret, Mowad Benguzzi, Nazeem Arsalan, N. Ishaque, R. Ashayeriahmadabad, Robert Samiento, Sanjay Mishra, Saeed Hosseini, Sajida Kazi, Saurav Das, T. Sugumar, Atif Zafar, D. Selchen, Pawel Kostyrko, Alexandra Muccilli, Gustavo Saposnik, Stefan Greisenegger, Klaus Werner, Sonja Wieszmuellner, A. Langer, Anna Gisold, Heidemarie Zach, Paulus Rommer, Susanne Macher, Stephan Blechinger, Wolfgang Marik, Wolfgang Series, Julia Ferrari, M. Baumgartinger, Stefan Krebs, Luciana Catanese, C. Vandervelde, Kanchana Ratnayake, Sally J. McMillan, Aristeidis H. Katsanos, Ashkan Shoamanesh, Demetrios J. Sahlas, George Medvedev, Vinny Naidoo, Vladimir Todorov, H Toma, J.S. Brar, Mike Horton, Elaine Shand, S Weatherb, A. Jin, Bryce A. Durafourt, Shirin Jalini, Gary Hunter, Aaron Gardner, Christopher Tyson, Emily Junk, Kimberley Foster, Kala Bolt, Nicole J. Sylvain, S Maley, Lilian Urroz, Lissa Peeling, Michael Kelly, R Whelan, R Cooley, Jeanne Teitelbaum, Alaae Boutayeb, Angela Moore, Edward Cole, Lloyd Waxman, Nadia Ben-Amor, R Sanchez, Sara Khalil, Ahmad Nehme, Claudine Legault, Donatella Tampieri, Eric Ehrensperger, Luciane Cristina Vieira, M Cortes, Mark Angle, Mathew Hannouche, Mohamed Badawy, Daniel Strbian, J. M. Koski, S. Eirola, Terhi Ivanoff, Anu Erakanto, Laura-Leena Kupari, Gerli Sibolt, Joni Panula, Liisa Tomppo, Marjaana Tiainen, Matti Ahlström, N Martinez Majander, O Suomalainen, Silja Räty, Christopher Levi, Neil J. Spratt, Enda Kerr, Jason W. Allen, Lara Kaauwai, Linda Belevski, Matthew Russell, Sally Ormond, Andrew Chew, Alayna E. Loiselle, Angela Royan, Brett Hughes, Carlos García Esperón, Elizabeth Pepper, Ferdinand Miteff, Jiang He, Mitchell Lycett, Michelle S. Min, Nigel P Murray, Nils Pavey, R. Starling de Barros, Sidhu P. Gangadharan, S. Dunkerton, Stephen G. Waller, Tamara Canento Sánchez, Tom Wellings, Darshan Ghia, Grant W. Edmonds, Karen Whittaker, P Lee, Rowena Singkang, Arline McDonald, Angela Dos Santos, Cha‐Nam Shin, David M. Jackson, Jessica Tsoleridis, Laura Fisicchia, Nick Parsons, Nandita Shenoy, Albert V. Smith, Angelos Sharobeam, Anna Balabanski, A‐La Park, Clare Williams, Davor Pavlin-Premri, E Rodrigues, Fana Alemseged, Felix Ng, Hang Zhao, James Beharry, John Ng, J Williamson, J.Z.W. Wong, Karlin Li, Michael Kwan, Mark Parsons, Michael Valente, Nawaf Yassi, Vignan Yogendrakumar, B. McNamara, Claire Buchanan, Christine McCarthy, George Thomas, Katharine Stephens, M.F. Chung, Min Tang, Naila Pachani, N Stuart, R Lee, Tanya Frost, Theresa M. Busch, Mina K. Chung, A. Menon, Branko Borojevic, Chris Linton, E.P. Callaly, HM Dewey, Jianjun Liu, Jingwen Chen, John Wong, Konrad Nowak, Karen To, Nathaniel Lizak, Oneil G. Bhalala, P Park, Patrick Tan, Rui Martins, Robert Cody, Raeburn B Forbes, S K Chen, Shengxian Tu, Sze‐Yuan Ooi, Yan L. Dang, Zhiyu Ling, Richard H. Drew, Ai Ling Tan, Craig Kurunawai, Jacquelyn Harvey, Jeyaledchumy Mahadevan, Lavenia Cagi, Logesh Palanikumar, N Chia, Rachel Goh, Shaddy El‐Masri, Peter Bailey, Primary Study Coordinators, Berzenn Urbi, C Rapier, Haylee Berrill, H C McEvoy, R. W. Dunning, Santhosh Kuriakose, Thomas Chad, V. Sapaen, Amin Sabet, Darshan Shah, David Gan Eng Yeow, Kathryn S. Lilley, Kathleen Ward, M Mozhy Mahizhnan, M. Tan, Peter J. Kelly, Christopher J. Lynch, Sarah Coveney, Karin E. Tobin, John McCabe, Michael Marnane, Shelley L. Murphy, David Williams, Matthew Large, B. Moynihan, K Boyle, Estela Sanjuán, M. J. Sanchı́s, Olalla Pancorbo, V. Sala, Lourdes R. García, Álvaro García‐Tornel, Jesús Juega, Jorge Pagola, K. Santana, Manuel Requena, Marián Muchada, Montse Olivé, Marta Rubiera, Matías Deck, Noelia Rodríguez, Pardo Lozano, Sandra Boned, Juan F. Arenillas, Bárbara Gómez, F J Reyes Munoz, Ángela Sánchez‐Algaba Gómez, AI Calleja Sanz, E Cortijo Garcia, G. Valle Peñacoba, Mark E. Ramos, M. De Lera Alfonso, Anna Feliu, Laura Pardo, Paula Ramírez, Ana Isabel Lopez Murillo, D Lopez Dominguez, J Rodríguez, Mikel Terceño Izaga, Manuel Reina, Urszula Bojaryn, Victor Augusto Vera Monge, R. R Siew, Sherwin J. U. Agustin, Christopher Seet, Teddy Y. Wu, A. d'Emden, Andrew J. Murray, Angela Welch, Kim Hatherley, Nicola C. Day, Wendy M. Smith, E MacRae, Suzanne Mitchell, Ammad Mahmood, J. Elliot, Stuart Neilson, Viveka Biswas, C Brown, Robert Simister, Adam Lewis, Amy Ashton, AE Black, A. Robinson, Andrew Williams, A. Banaras, Cyrille Cahoy, Georgia Raingold, Mark Marinescu, Ndifreke Atang, Nathalie Bason, Nadia Francia, R Muhammad, S Obarey, Shez Feerick, Yi‐Chung Lee, David J. Werring, Richard Perry, J. Kennedy, Joanne Joseph, John T. Benjamin, Linda Quinn, Monica Jhoots, Rachel Teal, Gary A. Ford, George Harston, H Bains, Ivie Gbinigie, P Mathieson, Robert Irons, U Schulz, Brian Clarke, Cai Sim, Elizabeth Hayter, Kathleen A. Kennedy, Lauren Binnie, Naomi Priestley, Rhys Williams, Rita Ghatala, Samuel J. Stratton, K Chatterjee, Andrew Davies, Helen Duffy, Jill Roberts, Jack Homer, Karen Roberts, Kenneth W. Dodd, Kathryn Cawley, Carmen Martín, S Leason, Susan Cotgreave, Tracey Taylor, Arumugan Nallasivan, Shozeb Haider, Tia Chakraborty, Thomas J. Webster, Omid Halse, Bryan Martin, B Joseph, Cecilia Cabrera, David José, Johnathan Man, Jhoanna N. Aquino, L. A. Sebastian, Maria Österdahl, M Matthew, N Ike, P Bello, Peter Wilding, Rodrigo Fuentes, Ruchir Shah, S Mashate, Tejas Patel, U Nwanguma, Vivek Pravin Dave, Abdel-Ghanny M El-Masry, Asim A. Sheikh, Amanda Dawson, A. Haber, Andrew Lee, Anne O’Sullivan, Brendan Drumm, Claire O'Hare, Derek J. Roberts, D Kalladka, Emma Taylor, Elisabeth Rounis, Frederick W. Vonberg, I. H. Jenkins, Jelena Blagojević, Jacob George, Joseph Kwan, M. A. Saeed, Michael D. Evans, Michael Haji-Coll, Masaki Tsuda, M Sayed, Narmathey Thanbirajah, Nicholas Winterkron, Oishik Raha, Orsolya Vittay, Rezaul Karim, Ruaridh Cameron Smail, Shahnaz Gauhar, Sadaf Kalam, Salwa Elmamoun, Susheel K. Malani, Shyam Kelavkar, Selin Doğan Jamil, Jacques Auger, T. Matar, Christine Roffe, Joanne Hiden, R. Varquez, Phillip Ferdinand, R. Sanyal, Ivan Wiggam, Bryn M. Smith, Chidiebere Emmanuel Okechukwu, Edward Fox, Érin Collins, Kelly E. Courtney, Sudhir Tauro, C. C. Patterson, Dennis J. McShane, Geraint Roberts, Jim McIImoyle, KP McGuire, Paul Fearon, P. Gordon, M Willmot, K Isaacs, Kayla V Lucas, L. D. Smith, Lucie Dews, M. Bates, S Lawrence, Susan Heeley, Vivek P. Patel, Y Chin, Don Sims, Edward Littleton, J Khaira, KarthickT Nadar, S. Ankolekar, Agnieszka Kieliszkowska, Bektaş Sarı, Caroline Domingos Belo, Erika Manolo, J Aeron‐Thomas, Mary H. Doheny, M Garcia Pardo, Mónica Recamán, Maria Tibajia, M Aissa, Samantha Bayhonan, Sean Conway, Ajay Bhalla, Anish Engineer, Dimitrios Nouvakis, Evangelia Theochari, F. Boyle, James Teo, Josh King‐Robson, K.Y. Law, L. Sztriha, Matthew Benger, Mohamed Farag, O. Dale Williams, Rana Alnasser Alsukhni, S Heller, S Meenakshisundaram, Tao Yu, Yee‐Haur Mah, Geevar Zachariah, Andrew McGovern, Arshad Muhammad Iqbal, Diana J. Day, J. Mitchell-Douglas, Joseph Francis, Puja Punjabivaryani, Javier Reyes, Mehrnoosh Pauls, M Anonuevo Reyes, Kailash Krishnan, Ashesh N. Buch, A Hedstrom, Cary T. Hutchinson, Christopher L. Kirkland, Gail M. Wilkes, James Newham, Lorraine Fleming, Sheila Cristina Ouriques Martins, N.A. Fleck, Aldi Fernandes de Souza França, Arthur Pille, Bruna Cristine Chwal, Carolina Oldoni, G. Mantovani, G Noll, Luca Zanella, Maurizio R. Soma, T Secchi, Wyllians Vendramini Borelli, O Neto, Brunna Rimoli, G. Silva, Leila Aparecida Machado Galvao Mondin, Riccardo Cerantola, Alexandre Kracker Imthon, Atsushi ESAKI, Ana Leticia Amorim de Albuquerque, Andréia Martini Pazini, Carlos Massote Fontanini, C.F. Matinez Rubio, C. Milani, Davi Teixeira dos Santos, F. A. Dias, F.F.A. Alves, Guilherme Gualberto Rodrigues, Kathleen Ferreira, Marjorie Ariele Pereira, Matheus Bernardon Morillos, Millene Rodrigues Camilo, Otavio Costa Vincenzi, Raulle Sol Cruz, Rodrigo Bazán, Bruno Pegorer Santos, F Winckler, Jorge Teodoro de Souza, Luana Aparecido Muondo Bonome, Nuno Cordeiro Ferreira, Daniel Fabiano Barbosa dos Santos, Gabriel Pinheiro Módolo, Julio Cesar dos Santos Moreira, Robson Sarmento Teodoro, V.A. Cury Silva, Fabrício Oliveira Lima, Alessandra Braga Cruz Guedes de Morais, J. Vieira, G Mendes, Joao Paulo de Queiroz
Notice bibliographique
RevueJournal of the American Heart Association · 2025
Typearticle
Langueen
DomaineMedicine
ThématiqueAcute Ischemic Stroke Management
Établissements canadiensQueen's UniversityUniversity of AlbertaUniversity of CalgaryUniversity of British ColumbiaHealth Sciences CentreSunnybrook Health Science Centre
Organismes subventionnairesBritish Heart Foundation
Mots-clésTenecteplaseMedicineModified Rankin ScaleStroke (engine)Randomized controlled trialFibrinolytic agentRandomizationOdds ratioInternal medicineTissue plasminogen activatorMyocardial infarctionThrombolysisIschemiaIschemic stroke
Résumé
BACKGROUND: In this subanalysis of the TEMPO-2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and symptomatic intracranial occlusion, we investigated sex differences in the efficacy and safety of tenecteplase. METHODS: We compared outcomes after tenecteplase versus control, stratified by sex. We also compared outcomes in female versus male patients treated with tenecteplase. The primary outcome was a "responder" outcome, defined as return to baseline modified Rankin Scale score at 90 days. Secondary outcomes included the Lawton Instrumental Activities of Daily Living Scale, the EuroQol-5 Dimension, vessel recanalization, and adverse events. We used generalized linear modeling with a Poisson distribution adjusted for baseline differences to calculate adjusted risk ratios (aRR) and 95% CIs. RESULTS: There were 884 patients in the intention-to-treat analysis (48.9% tenecteplase, 41.5% female). Among female participants, the tenecteplase group was less likely to be a responder compared with control (63.8% tenecteplase, 73.9% control, aRR, 0.87 [95% CI, 0.76-1.00]). Among male participants, the responder outcome was similar between groups (77.5% tenecteplase, 75.4% control, 1.03 [95% CI, 0.94-1.13]). Female participants randomized to tenecteplase were less likely to be responders than male counterparts (63.8% female, 77.5% male, 0.85 [95% CI, 0.75-0.96]). Early recanalization was more frequent after tenecteplase than control in both sexes. CONCLUSIONS: Tenecteplase was not associated with better clinical outcomes over nonthrombolytic control in female or male patients with minor ischemic stroke, despite more frequent recanalization. Fewer women treated with tenecteplase returned to baseline function compared with men.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
score de la tête « metaresearch » (Codex)0,008
score de la tête « metaresearch » (Gemma)0,008
Version: metacan-v3-hybrid-931329e0061cStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Observationnel · Signal consensuel: aucune
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,008
Score d'incertitude au seuil0,040
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,008 | 0,008 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,003 | 0,006 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Tête enseignante Opus0,011
Tête enseignante GPT0,289
Écart entre enseignants0,278 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validation
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeObservationnel
Domainenon disponible
GenreEmpirique
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».
En bref
Citations1
Publié2025
Routes d'admission1
Résumé présentoui