← Back to cohort
Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial
Amy Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia S. Field, Philip A. Barber, Philip Choi, Brian Buck, Timothy Kleinig, Carlos A. Molina, Bruce Campbell, Ramana Appireddy, Keith W. Muir, Michael D. Hill, Shelagh B. Coutts, Marina Salluzzi, Nicole Blenkin, Ashley Dueck, Craig Doram, Qiao Zhang, Carol Kenney, Charlotte Zerna, Karla J. Ryckborst, Shelly Bohn, Dar Dowlatshahi, Robert J. Hard, David M. Kent, Renee Martin, William Whiteley, Quinten Collier, Frances Taylor, Brendan Cord Lethebe, PA Barber, C Kenney, Anitha Jambula, Karen Sage, Loren Toussaint, Sushma Save, Jungwha Lee, Nihay Laham-Karam, Assem A. Sultan, Aimen Moussaddy, Akshay Deepak, A Sitaram, Andrew M. Demchuk, Andrew Lockey, Andrew Micielli, Ankur Wadhwa, Babawale Arabambi, Bijoy K. Menon, B Graham, Clement C. Tham, Chrysi Bogiatzi, Dolar Doshi, Debabrata Chakraborty, Do Young Kim, Denise Vasquez, Dolly Singh, Darren Tse, Earl C. Harrison, Eric E. Smith, Erika Teleg, Evgenia Klourfeld, Gary Klein, Ivy Sebastian, J. Grimley Evans, Janka Hegedus, Julie Kromm, Katie Lin, Katrina Hannah D. Ignacio, Khosrow Ghavami, Mohammed Ismail, Margaret Moores, Marie-Andrée Panzini, Martha Marko, Matthew Boyko, Mohammed Almekhlafi, Nancy Newcommon, Nicholar Maraj, Nishita Singh, Oje Imoukhuede, Ondřej Volný, Peter K. Stys, P Couillard, Piyush Ojha, PrasannaVenkatesan Eswaradass, RA Joundi, Rajesh Kumar Singh, R.M. Asuncion, Ryan T. Muir, Subhalaxmi Dey, Sana Mansoor, Sanchea Wasyliw, S Nagendra, Shiyu Hu, Shorog Althubait, Shuo Chen, Simerpreet Bal, Stephen van Gaal, Sanne A. E. Peters, Sucharita Ray, S. K. Chaturvedi, Suresh Subramaniam, Vivian Fu, Karina Villaluna, G. L. Maclean, Princess King-Azote, Chaoyang Ma, Alyson Plecash, Colleen Murphy, Laura Wilson, Oscar Benavente, P. Teal, Samuel Yip, Samuel J. Mann, B. Dewar, Michele Demetroff, Reham Shamloul, Rebeccah Beardshaw, Susan B. Roberts, Dylan Blaquiere, Grant Stotts, Michel Shamy, Olena Bereznyakova, Robert Fahed, Walid Alesefir, Marie‐Christine Camden, Suzy Lavoie, Annette Haché, Karine Collard, Ariane Mackey, Stéphanie Gosselin-Lefebvre, Steve Verreault, Jennifer Mandzia, Beth Beauchamp, Lindsay Lambourn, Alexander V. Khaw, L. Mai, Luciano A. Sposato, María Bres Bullrich, R. Azarpazhooh, Sebastián Fridman, Arunima Kapoor, Angela Southwell, Edoardo Bardi, Idris Fatakdawala, Maneesha Kamra, Kaitlynn M. Lopes, Najla Popel, Vanessa Norouzi, Aihua Liu, Ann-Marie Liddy, Bismah Ghoari, Colin P. Hawkes, C.A. Enriquez, David J. Gladstone, Herbert Alejandro Manosalva Alzate, Houman Khosravani, Julia Hopyan, Kousik Sivakumar, Mia Son, Mark I. Boulos, M.A. Hamind, Richard H. Swartz, Robert Murphy, Stephanie Reiter, Thomas Fitzpatrick, Virendra Bhandari, Andrew M. Penn, J Good, Melanie Penn, Mary D. Naylor, Steven A. Frost, Leanne K. Casaubon, Anne Cayley, Farhana Akthar, David Williams, L Kalman, Lisa Crellin, Rebecca Wiegner, Sarman Singh, Thomas G. Stewart, Wing Kin To, Aleksandra Pikula, Cheryl Jaigobin, Federico Carpani, Frank L. Silver, Heidi Janssen, Joanna D. Schaafsma, Miguel Del Campo, Mohammed A. Alskaini, Phavalan Rajendram, Paige Fairall, Bonny Granfield, Dorothy H. Crawford, Juline Jabs, Laura White, Leka Sivakumar, Lori Piquette, Thanh N. Nguyen, Alireza Nomani, Aaron Wagner, A Alrohimi, Adeel A. Butt, Alicia D’Souza, Bikram Prasad Gajurel, Chetan Vekhande, Hemant Kamble, Hayrapet Kalashyan, Kenneth Butcher, María Jesús Lloret, Mowad Benguzzi, Nazeem Arsalan, N. Ishaque, R. Ashayeriahmadabad, Robert Samiento, Sanjay Mishra, Saeed Hosseini, Sajida Kazi, Saurav Das, T. Sugumar, Atif Zafar, D. Selchen, Pawel Kostyrko, Alexandra Muccilli, Gustavo Saposnik, Stefan Greisenegger, Klaus Werner, Sonja Wieszmuellner, A. Langer, Anna Gisold, Heidemarie Zach, Paulus Rommer, Susanne Macher, Stephan Blechinger, Wolfgang Marik, Wolfgang Series, Julia Ferrari, M. Baumgartinger, Stefan Krebs, Luciana Catanese, C. Vandervelde, Kanchana Ratnayake, Sally J. McMillan, Aristeidis H. Katsanos, Ashkan Shoamanesh, Demetrios J. Sahlas, George Medvedev, Vinny Naidoo, Vladimir Todorov, H Toma, J.S. Brar, Mike Horton, Elaine Shand, S Weatherb, A. Jin, Bryce A. Durafourt, Shirin Jalini, Gary Hunter, Aaron Gardner, Christopher Tyson, Emily Junk, Kimberley Foster, Kala Bolt, Nicole J. Sylvain, S Maley, Lilian Urroz, Lissa Peeling, Michael Kelly, R Whelan, R Cooley, Jeanne Teitelbaum, Alaae Boutayeb, Angela Moore, Edward Cole, Lloyd Waxman, Nadia Ben-Amor, R Sanchez, Sara Khalil, Ahmad Nehme, Claudine Legault, Donatella Tampieri, Eric Ehrensperger, Luciane Cristina Vieira, M Cortes, Mark Angle, Mathew Hannouche, Mohamed Badawy, Daniel Strbian, J. M. Koski, S. Eirola, Terhi Ivanoff, Anu Erakanto, Laura-Leena Kupari, Gerli Sibolt, Joni Panula, Liisa Tomppo, Marjaana Tiainen, Matti Ahlström, N Martinez Majander, O Suomalainen, Silja Räty, Christopher Levi, Neil J. Spratt, Enda Kerr, Jason W. Allen, Lara Kaauwai, Linda Belevski, Matthew Russell, Sally Ormond, Andrew Chew, Alayna E. Loiselle, Angela Royan, Brett Hughes, Carlos García Esperón, Elizabeth Pepper, Ferdinand Miteff, Jiang He, Mitchell Lycett, Michelle S. Min, Nigel P Murray, Nils Pavey, R. Starling de Barros, Sidhu P. Gangadharan, S. Dunkerton, Stephen G. Waller, Tamara Canento Sánchez, Tom Wellings, Darshan Ghia, Grant W. Edmonds, Karen Whittaker, P Lee, Rowena Singkang, Arline McDonald, Angela Dos Santos, Cha‐Nam Shin, David M. Jackson, Jessica Tsoleridis, Laura Fisicchia, Nick Parsons, Nandita Shenoy, Albert V. Smith, Angelos Sharobeam, Anna Balabanski, A‐La Park, Clare Williams, Davor Pavlin-Premri, E Rodrigues, Fana Alemseged, Felix Ng, Hang Zhao, James Beharry, John Ng, J Williamson, J.Z.W. Wong, Karlin Li, Michael Kwan, Mark Parsons, Michael Valente, Nawaf Yassi, Vignan Yogendrakumar, B. McNamara, Claire Buchanan, Christine McCarthy, George Thomas, Katharine Stephens, M.F. Chung, Min Tang, Naila Pachani, N Stuart, R Lee, Tanya Frost, Theresa M. Busch, Mina K. Chung, A. Menon, Branko Borojevic, Chris Linton, E.P. Callaly, HM Dewey, Jianjun Liu, Jingwen Chen, John Wong, Konrad Nowak, Karen To, Nathaniel Lizak, Oneil G. Bhalala, P Park, Patrick Tan, Rui Martins, Robert Cody, Raeburn B Forbes, S K Chen, Shengxian Tu, Sze‐Yuan Ooi, Yan L. Dang, Zhiyu Ling, Richard H. Drew, Ai Ling Tan, Craig Kurunawai, Jacquelyn Harvey, Jeyaledchumy Mahadevan, Lavenia Cagi, Logesh Palanikumar, N Chia, Rachel Goh, Shaddy El‐Masri, Peter Bailey, Primary Study Coordinators, Berzenn Urbi, C Rapier, Haylee Berrill, H C McEvoy, R. W. Dunning, Santhosh Kuriakose, Thomas Chad, V. Sapaen, Amin Sabet, Darshan Shah, David Gan Eng Yeow, Kathryn S. Lilley, Kathleen Ward, M Mozhy Mahizhnan, M. Tan, Peter J. Kelly, Christopher J. Lynch, Sarah Coveney, Karin E. Tobin, John McCabe, Michael Marnane, Shelley L. Murphy, David Williams, Matthew Large, B. Moynihan, K Boyle, Estela Sanjuán, M. J. Sanchı́s, Olalla Pancorbo, V. Sala, Lourdes R. García, Álvaro García‐Tornel, Jesús Juega, Jorge Pagola, K. Santana, Manuel Requena, Marián Muchada, Montse Olivé, Marta Rubiera, Matías Deck, Noelia Rodríguez, Pardo Lozano, Sandra Boned, Juan F. Arenillas, Bárbara Gómez, F J Reyes Munoz, Ángela Sánchez‐Algaba Gómez, AI Calleja Sanz, E Cortijo Garcia, G. Valle Peñacoba, Mark E. Ramos, M. De Lera Alfonso, Anna Feliu, Laura Pardo, Paula Ramírez, Ana Isabel Lopez Murillo, D Lopez Dominguez, J Rodríguez, Mikel Terceño Izaga, Manuel Reina, Urszula Bojaryn, Victor Augusto Vera Monge, R. R Siew, Sherwin J. U. Agustin, Christopher Seet, Teddy Y. Wu, A. d'Emden, Andrew J. Murray, Angela Welch, Kim Hatherley, Nicola C. Day, Wendy M. Smith, E MacRae, Suzanne Mitchell, Ammad Mahmood, J. Elliot, Stuart Neilson, Viveka Biswas, C Brown, Robert Simister, Adam Lewis, Amy Ashton, AE Black, A. Robinson, Andrew Williams, A. Banaras, Cyrille Cahoy, Georgia Raingold, Mark Marinescu, Ndifreke Atang, Nathalie Bason, Nadia Francia, R Muhammad, S Obarey, Shez Feerick, Yi‐Chung Lee, David J. Werring, Richard Perry, J. Kennedy, Joanne Joseph, John T. Benjamin, Linda Quinn, Monica Jhoots, Rachel Teal, Gary A. Ford, George Harston, H Bains, Ivie Gbinigie, P Mathieson, Robert Irons, U Schulz, Brian Clarke, Cai Sim, Elizabeth Hayter, Kathleen A. Kennedy, Lauren Binnie, Naomi Priestley, Rhys Williams, Rita Ghatala, Samuel J. Stratton, K Chatterjee, Andrew Davies, Helen Duffy, Jill Roberts, Jack Homer, Karen Roberts, Kenneth W. Dodd, Kathryn Cawley, Carmen Martín, S Leason, Susan Cotgreave, Tracey Taylor, Arumugan Nallasivan, Shozeb Haider, Tia Chakraborty, Thomas J. Webster, Omid Halse, Bryan Martin, B Joseph, Cecilia Cabrera, David José, Johnathan Man, Jhoanna N. Aquino, L. A. Sebastian, Maria Österdahl, M Matthew, N Ike, P Bello, Peter Wilding, Rodrigo Fuentes, Ruchir Shah, S Mashate, Tejas Patel, U Nwanguma, Vivek Pravin Dave, Abdel-Ghanny M El-Masry, Asim A. Sheikh, Amanda Dawson, A. Haber, Andrew Lee, Anne O’Sullivan, Brendan Drumm, Claire O'Hare, Derek J. Roberts, D Kalladka, Emma Taylor, Elisabeth Rounis, Frederick W. Vonberg, I. H. Jenkins, Jelena Blagojević, Jacob George, Joseph Kwan, M. A. Saeed, Michael D. Evans, Michael Haji-Coll, Masaki Tsuda, M Sayed, Narmathey Thanbirajah, Nicholas Winterkron, Oishik Raha, Orsolya Vittay, Rezaul Karim, Ruaridh Cameron Smail, Shahnaz Gauhar, Sadaf Kalam, Salwa Elmamoun, Susheel K. Malani, Shyam Kelavkar, Selin Doğan Jamil, Jacques Auger, T. Matar, Christine Roffe, Joanne Hiden, R. Varquez, Phillip Ferdinand, R. Sanyal, Ivan Wiggam, Bryn M. Smith, Chidiebere Emmanuel Okechukwu, Edward Fox, Érin Collins, Kelly E. Courtney, Sudhir Tauro, C. C. Patterson, Dennis J. McShane, Geraint Roberts, Jim McIImoyle, KP McGuire, Paul Fearon, P. Gordon, M Willmot, K Isaacs, Kayla V Lucas, L. D. Smith, Lucie Dews, M. Bates, S Lawrence, Susan Heeley, Vivek P. Patel, Y Chin, Don Sims, Edward Littleton, J Khaira, KarthickT Nadar, S. Ankolekar, Agnieszka Kieliszkowska, Bektaş Sarı, Caroline Domingos Belo, Erika Manolo, J Aeron‐Thomas, Mary H. Doheny, M Garcia Pardo, Mónica Recamán, Maria Tibajia, M Aissa, Samantha Bayhonan, Sean Conway, Ajay Bhalla, Anish Engineer, Dimitrios Nouvakis, Evangelia Theochari, F. Boyle, James Teo, Josh King‐Robson, K.Y. Law, L. Sztriha, Matthew Benger, Mohamed Farag, O. Dale Williams, Rana Alnasser Alsukhni, S Heller, S Meenakshisundaram, Tao Yu, Yee‐Haur Mah, Geevar Zachariah, Andrew McGovern, Arshad Muhammad Iqbal, Diana J. Day, J. Mitchell-Douglas, Joseph Francis, Puja Punjabivaryani, Javier Reyes, Mehrnoosh Pauls, M Anonuevo Reyes, Kailash Krishnan, Ashesh N. Buch, A Hedstrom, Cary T. Hutchinson, Christopher L. Kirkland, Gail M. Wilkes, James Newham, Lorraine Fleming, Sheila Cristina Ouriques Martins, N.A. Fleck, Aldi Fernandes de Souza França, Arthur Pille, Bruna Cristine Chwal, Carolina Oldoni, G. Mantovani, G Noll, Luca Zanella, Maurizio R. Soma, T Secchi, Wyllians Vendramini Borelli, O Neto, Brunna Rimoli, G. Silva, Leila Aparecida Machado Galvao Mondin, Riccardo Cerantola, Alexandre Kracker Imthon, Atsushi ESAKI, Ana Leticia Amorim de Albuquerque, Andréia Martini Pazini, Carlos Massote Fontanini, C.F. Matinez Rubio, C. Milani, Davi Teixeira dos Santos, F. A. Dias, F.F.A. Alves, Guilherme Gualberto Rodrigues, Kathleen Ferreira, Marjorie Ariele Pereira, Matheus Bernardon Morillos, Millene Rodrigues Camilo, Otavio Costa Vincenzi, Raulle Sol Cruz, Rodrigo Bazán, Bruno Pegorer Santos, F Winckler, Jorge Teodoro de Souza, Luana Aparecido Muondo Bonome, Nuno Cordeiro Ferreira, Daniel Fabiano Barbosa dos Santos, Gabriel Pinheiro Módolo, Julio Cesar dos Santos Moreira, Robson Sarmento Teodoro, V.A. Cury Silva, Fabrício Oliveira Lima, Alessandra Braga Cruz Guedes de Morais, J. Vieira, G Mendes, Joao Paulo de Queiroz
Bibliographic record
VenueJournal of the American Heart Association · 2025
Typearticle
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsQueen's UniversityUniversity of AlbertaUniversity of CalgaryUniversity of British ColumbiaHealth Sciences CentreSunnybrook Health Science Centre
FundersBritish Heart Foundation
KeywordsTenecteplaseMedicineModified Rankin ScaleStroke (engine)Randomized controlled trialFibrinolytic agentRandomizationOdds ratioInternal medicineTissue plasminogen activatorMyocardial infarctionThrombolysisIschemiaIschemic stroke
Abstract
BACKGROUND: In this subanalysis of the TEMPO-2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and symptomatic intracranial occlusion, we investigated sex differences in the efficacy and safety of tenecteplase. METHODS: We compared outcomes after tenecteplase versus control, stratified by sex. We also compared outcomes in female versus male patients treated with tenecteplase. The primary outcome was a "responder" outcome, defined as return to baseline modified Rankin Scale score at 90 days. Secondary outcomes included the Lawton Instrumental Activities of Daily Living Scale, the EuroQol-5 Dimension, vessel recanalization, and adverse events. We used generalized linear modeling with a Poisson distribution adjusted for baseline differences to calculate adjusted risk ratios (aRR) and 95% CIs. RESULTS: There were 884 patients in the intention-to-treat analysis (48.9% tenecteplase, 41.5% female). Among female participants, the tenecteplase group was less likely to be a responder compared with control (63.8% tenecteplase, 73.9% control, aRR, 0.87 [95% CI, 0.76-1.00]). Among male participants, the responder outcome was similar between groups (77.5% tenecteplase, 75.4% control, 1.03 [95% CI, 0.94-1.13]). Female participants randomized to tenecteplase were less likely to be responders than male counterparts (63.8% female, 77.5% male, 0.85 [95% CI, 0.75-0.96]). Early recanalization was more frequent after tenecteplase than control in both sexes. CONCLUSIONS: Tenecteplase was not associated with better clinical outcomes over nonthrombolytic control in female or male patients with minor ischemic stroke, despite more frequent recanalization. Fewer women treated with tenecteplase returned to baseline function compared with men.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.008
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.040
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.008 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.006 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.011
GPT teacher head0.289
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations1
Published2025
Admission routes1
Has abstractyes