Progression of Atherosclerosis and Hypothesis on the Relationship Between Microvascular Dysfunction, Cardiovascular Risk, and Cancer
Notice bibliographique
Résumé
Background: The extent of atherosclerosis in healthy men and women was measured using ultrasound in the carotid artery and whether the progression could be predicted using the classic risk factors was investigated. A hypothesis was also formulated as to how microvascular dysfunction and atherosclerosis, on the one hand, and cardiovascular disease and cancer, on the other hand, might be related. To describe the relationship between atherosclerosis and cancer, the classic risk factors and plaque burden were compared. Methods: From 2009 to 2024, 10,597 subjects (44% women) aged 20 - 65 years without signs of cardiovascular disease were examined using ultrasound of the carotid artery. The sum of all plaque areas (total plaque area (TPA)) and the maximum plaque thickness were measured. Follow-up examinations were carried out on 4,520 subjects (42% women) aged 40 - 65 years. In 2,397 men without cancer or cardiovascular events during follow-up, the classic risk factors and plaque burden were compared between 55 men who had a solid tumor and 188 men who had a cardiovascular event, and whether patients with cancer and a cardiovascular event exhibited different risk profiles was examined. Results: In the age group of 35 - 65 years, 12% of men and 4.2% of women had advanced atherosclerosis (types III and IVb). In the age group of 40 - 65 years, 2,592 men and 1,928 women were followed up. Low to moderate atherosclerosis was present in 2,052 (79.2%) men and 1,761 (91.3%) women. Advanced atherosclerosis developed in 139 (6.8%) men and 39 (2.2%) women, which could not be predicted by the classical risk factors (P > 0.05). The mean follow-up time was 73 months (6.1 years) for men and 75 months (6.3 years) for women. Patients without cancer or cardiovascular disease have lower risk factors and lower plaque burden compared to men with cancer or cardiovascular events. Patients with cancer have very similar high-risk factors and high plaque burden compared to patients with cardiovascular disease. Conclusion: By measuring the plaque burden on the carotid artery, a good risk stratification can be achieved in every age group. A follow-up examination every 3 - 5 years is advisable, as a rapid progression of the disease cannot be predicted taking into account the classic risk factors. Early treatment of advanced atherosclerosis improves the prognosis for cardiovascular diseases and possibly also for certain types of cancer. Patients with cancer and cardiovascular events show a similar risk profile and plaque burden.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».