Perception of Biologics in Adults With Asthma and CRSwNP: International Survey Results
Notice bibliographique
Résumé
Abstract Rationale: Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) can be treated with biologics that target Type 2 inflammation. The survey objective was to seek insight into perceptions of biologics in adults with asthma, CRSwNP, or both. Methods: An anonymous survey was conducted online February-May 2024 recruited participants aged ≥18 years from the US, Canada, UK, Germany, Italy, France, or Spain through social media and by Survey Monkey. Results: Of 1566 survey participants (56.7% asthma, 24.8% CRSwNP, 18.5% both), 52.5% were female, and 65.2% were ages 25-54 years; 14% (195/1410 responses) were currently using a biologic; 69% (135/195 responses) had been on the biologic for less than 2 years. Of those receiving a biologic, 37% (73/195) inject it themselves and feel confident doing so. The remaining 63% either worry they are not doing it correctly or have someone else do the injection. Participants over age 45 years appear more likely than younger participants to self-inject and feel confident doing so, but more than 25% of those over the age of 65 receive the injection from a family member or friend.Nearly half (42%; 82/195) felt that taking the biologic was a repeating reminder of the chronic nature of their condition; 33% worry about missing a dose or forgetting to take their injection. When given a list of reasons why people may not take their medications exactly as prescribed by their doctor, participants selected frequency of the medication (e.g., too often) as the top reason, followed by the way the medication needs to be taken (injection). A third of participants not currently on biologics (34%; 390/1156) reported they had taken an injectable biologic in the past which they had stopped taking. The top reasons for stopping treatment were the injection/device was too difficult, getting to the clinic was too difficult, and the injection was too expensive (Figure). More than two-thirds (68%; 934/1378) would consider a biologic injection if it was once every 6 months as part of their regular checkup; approximately half would consider a biologic treatment if the injection was twice a month (48%), once a month (53%), or every other month (56%). People with asthma and/or CRSwNP on biologics worry about doing the injections properly and view the them as a constant reminder of their chronic condition. Conclusion: Access to biologics that can be administered less frequently and in an easier manner may alleviate some of the burden of self-injection.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,005 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».