Perception of Biologics in Adults With Asthma and CRSwNP: International Survey Results
Bibliographic record
Abstract
Abstract Rationale: Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) can be treated with biologics that target Type 2 inflammation. The survey objective was to seek insight into perceptions of biologics in adults with asthma, CRSwNP, or both. Methods: An anonymous survey was conducted online February-May 2024 recruited participants aged ≥18 years from the US, Canada, UK, Germany, Italy, France, or Spain through social media and by Survey Monkey. Results: Of 1566 survey participants (56.7% asthma, 24.8% CRSwNP, 18.5% both), 52.5% were female, and 65.2% were ages 25-54 years; 14% (195/1410 responses) were currently using a biologic; 69% (135/195 responses) had been on the biologic for less than 2 years. Of those receiving a biologic, 37% (73/195) inject it themselves and feel confident doing so. The remaining 63% either worry they are not doing it correctly or have someone else do the injection. Participants over age 45 years appear more likely than younger participants to self-inject and feel confident doing so, but more than 25% of those over the age of 65 receive the injection from a family member or friend.Nearly half (42%; 82/195) felt that taking the biologic was a repeating reminder of the chronic nature of their condition; 33% worry about missing a dose or forgetting to take their injection. When given a list of reasons why people may not take their medications exactly as prescribed by their doctor, participants selected frequency of the medication (e.g., too often) as the top reason, followed by the way the medication needs to be taken (injection). A third of participants not currently on biologics (34%; 390/1156) reported they had taken an injectable biologic in the past which they had stopped taking. The top reasons for stopping treatment were the injection/device was too difficult, getting to the clinic was too difficult, and the injection was too expensive (Figure). More than two-thirds (68%; 934/1378) would consider a biologic injection if it was once every 6 months as part of their regular checkup; approximately half would consider a biologic treatment if the injection was twice a month (48%), once a month (53%), or every other month (56%). People with asthma and/or CRSwNP on biologics worry about doing the injections properly and view the them as a constant reminder of their chronic condition. Conclusion: Access to biologics that can be administered less frequently and in an easier manner may alleviate some of the burden of self-injection.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".