Retrospective Analysis of Patient Profiles and Disease Burden for Patients With Chronic Obstructive Pulmonary Disease Who Initiated Triple Therapy in China
Notice bibliographique
Résumé
Abstract RATIONALE In patients with chronic obstructive pulmonary disease (COPD) at risk of exacerbation, early treatment with triple therapy (TT) has been shown to reduce the risk of exacerbations, healthcare resource utilization (HRU), and costs. However, many patients with COPD in China at risk of exacerbations are not prescribed TT. One reason for this is that characteristics of patients most likely to benefit from TT are not always identified. This study aimed to describe demographics, characteristics, and disease burden for patients with COPD in China who initiated TT. METHODS This retrospective analysis using data from the Tianjin electronic medical database identified patients aged ≥40 years who initiated single-inhaler TT (SITT) with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) or budesonide/glycopyrronium/formoterol (BUD/GLY/FOR), or multiple-inhaler TT (MITT) between January 1, 2019-June 30, 2023. Index date was the first date of an episode for which TT was prescribed for 30 consecutive days. Patient characteristics and demographics, COPD-related HRU and costs, and eosinophil levels (EOS) were captured on the index date and during the baseline period (12 months pre-index). RESULTS Overall, 7871 patients were included in the overall population; 3582 and 4289 patients were included in the MITT and SITT subgroups, respectively. Among patients in the SITT subgroup, 508 received FF/UMEC/VI and 3781 received BUD/GLY/FOR. In the overall population, median age was 66 years, 64.8% of patients were male, and the annualized rate of exacerbations was 0.34 (Table). The most common comorbidities at baseline were hypertension (36.8%) and asthma (33.0%). The proportions of patients in the overall population with ≥1 COPD-related emergency department (ED) visit, inpatient admission, and outpatient admission were 7.0%, 10.8%, and 62.4%, respectively. The annualized rate of COPD-related ED visits, inpatient admissions, and outpatient admissions was 0.15, 0.15, and 2.71, respectively. The median COPD-related total direct medical cost (RMB) was 2068 per patient and 361 per patient per visit in the overall population. Of the 653 patients with reported EOS, 43.5% had EOS <100 cells/μL, 42.1% had EOS 100-<300 cells/μL, and 14.4% had EOS ≥300 cells/μL. The annualized rate of exacerbations was 0.84 among patients with available EOS and 0.30 among patients without available EOS. CONCLUSIONS This study found that patients with COPD who were prescribed TT in China had a median age of 66 years and 64.8% were male. The most common comorbidities at baseline were hypertension and asthma, and more than half of patients with reported EOS had EOS >100 cells/μL.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,002 | 0,003 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».