Trends of Congenital Pulmonary Airway Malformation (CPAMs) in Haidian District, Beijing, 2013-2023
Notice bibliographique
Résumé
Abstract Rationale Congenital pulmonary airway malformations or CPAMs were used to be an rare developmental lung malformations, leading to cystic and/or adenomatous pulmonary areas. Data from previous studies and the European Surveillance of Congenital Anomalies (EUROCAT) have both suggested that the true prevalence might be much higher than previously thought and increasing. Understanding the temporal trend of CPAMs and its further harm is important for effective prevention strategies and improvement. The aim of the study is to analyzed the prevalence of CPAM during 2013-2023, and explore its trend and further influence. Methods Following the data from a hospital-based birth-defect surveillance system in Haidian District, Beijing, the prevalence and proportion of CPAM were calculated by sex, gestational weeks, maternal age and outcomes from 2013 to 2023. The prevalence of CPAM and its distribution by demographic information were represented. The chi-square test and Fisher‘s exact test by using SPSS were used to compare the prevalence of CPAM. All data analyses were using SPSS, R studio and Joinpoint software. Results A total of 386,321 births were enrolled and 123 CPAM cases recorded in the district during 2013-2023. The average prevalence was 3.18/10,000 during the period, which was 2 times more than Europe, and showed an ridge-like increasing trend (APC = 6.60%, p = 0.06). Classified by the disease position, prevalence of CPAM in left lung showed a slightly fluctuate in the decade, but the prevalence of CPAM in right lung showed an significant increasing trend (APC = 17.48%, p = 0.004). Proportion of death by termination was also decreased during the same time, which has gradually approached the level of Europe. Considering that some type of CPAMs may have the possibility of carcinogenesis, although more fetuses were able to survive, the further follow-up would be more crucial for them. Conclusion Nowadays, with improving the prenatal and immediate postnatal care and maternal education of CPAMs, more and more CPAM were diagnosed prenatally and follow-up in Beijing. Due to effective surgery, more and more CPAM were surviving, but the risk of malignancy development remains the most worrying factor for doctors. After all, from a global perspective, this kind of disease was not monitored officially at first until early 1990 by Canada and Europe, so continuous monitoring the prognosis of CPAM is crucial for public health. We should strengthen follow-up and related examinations (including CT, lung function test and so on) for neonates of CPAMs.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».