1039 A Good Night’s Sleep? The Association Between Neurodevelopmental Disorders and Restless Sleep Disorder
Notice bibliographique
Résumé
Abstract Introduction Sleep disorders are prevalent in children and are associated with behavioral and neurocognitive impacts when left untreated. A recently identified sleep-related movement disorder, restless sleep disorder (RSD), is characterized by frequent body movements during sleep resulting in daytime impairment. RSD is diagnosed based on clinical symptoms as well as objective evidence of restless sleep on an overnight polysomnogram and improves with iron supplementation. Despite the frequent comorbidity of sleep disruption among children with neurodevelopmental disorders, there is a paucity of data assessing the association between RSD and neurodevelopmental disorders. Thus, we sought to evaluate the association between RSD and neurodevelopmental disorders in children. Methods This is an interim analysis of a retrospective study of children aged 6-18 years old who completed a baseline diagnostic polysomnogram at British Columbia Children’s Hospital between December 2023 – May 2024. Polysomnogram data was evaluated for large muscle movements according to the International Restless Legs Syndrome Study Group standards. Neurodevelopmental disorders were classified according to the DSM-5. Results There were 150 children (median age = 11 years, females = 57/154 (38.0%) and 57/150 (38.0%) had a neurodevelopmental disorder. In total, there were 23/150 (15.3%) children with RSD, 48/150 (32.0%) with moderate or severe obstructive sleep apnea, and 2/150 (1.3%) with restless legs syndrome. Of the children with neurodevelopmental disorders, 5/57 (8.8%) had RSD whereas 18/93 (19.4%) children without a neurodevelopmental disorder were found to have RSD (p = 0.081). Children with a neurodevelopmental disorder were more likely to receive iron supplementation (18% of children with neurodevelopmental disorders vs 3.9% of children without neurodevelopmental disorders; p=0.012), which may confound the results. Conclusion In this interim analysis, we did not find an association between neurodevelopmental disorders and RSD. However, children with neurodevelopmental disorders were more likely to receive iron supplementation, which may confound our results. Data collection is ongoing to better elucidate this relationship. Ultimately, the results of this study will examine the association between neurodevelopmental disorders and RSD to inform the need for the routine assessment of RSD in children with neurodevelopmental disorders. Support (if any) We thank the BC Children’s Hospital Research Institute for providing funding.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».