1039 A Good Night’s Sleep? The Association Between Neurodevelopmental Disorders and Restless Sleep Disorder
Bibliographic record
Abstract
Abstract Introduction Sleep disorders are prevalent in children and are associated with behavioral and neurocognitive impacts when left untreated. A recently identified sleep-related movement disorder, restless sleep disorder (RSD), is characterized by frequent body movements during sleep resulting in daytime impairment. RSD is diagnosed based on clinical symptoms as well as objective evidence of restless sleep on an overnight polysomnogram and improves with iron supplementation. Despite the frequent comorbidity of sleep disruption among children with neurodevelopmental disorders, there is a paucity of data assessing the association between RSD and neurodevelopmental disorders. Thus, we sought to evaluate the association between RSD and neurodevelopmental disorders in children. Methods This is an interim analysis of a retrospective study of children aged 6-18 years old who completed a baseline diagnostic polysomnogram at British Columbia Children’s Hospital between December 2023 – May 2024. Polysomnogram data was evaluated for large muscle movements according to the International Restless Legs Syndrome Study Group standards. Neurodevelopmental disorders were classified according to the DSM-5. Results There were 150 children (median age = 11 years, females = 57/154 (38.0%) and 57/150 (38.0%) had a neurodevelopmental disorder. In total, there were 23/150 (15.3%) children with RSD, 48/150 (32.0%) with moderate or severe obstructive sleep apnea, and 2/150 (1.3%) with restless legs syndrome. Of the children with neurodevelopmental disorders, 5/57 (8.8%) had RSD whereas 18/93 (19.4%) children without a neurodevelopmental disorder were found to have RSD (p = 0.081). Children with a neurodevelopmental disorder were more likely to receive iron supplementation (18% of children with neurodevelopmental disorders vs 3.9% of children without neurodevelopmental disorders; p=0.012), which may confound the results. Conclusion In this interim analysis, we did not find an association between neurodevelopmental disorders and RSD. However, children with neurodevelopmental disorders were more likely to receive iron supplementation, which may confound our results. Data collection is ongoing to better elucidate this relationship. Ultimately, the results of this study will examine the association between neurodevelopmental disorders and RSD to inform the need for the routine assessment of RSD in children with neurodevelopmental disorders. Support (if any) We thank the BC Children’s Hospital Research Institute for providing funding.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".