CALCINOSIS CUTIS IN LUPUS ERYTHEMATOSUS PANNICULITIS SHOW PREDILECTION FOR TRUNCAL LOCATION
Notice bibliographique
Résumé
PV061 / #136 Poster Topic: AS07 - Cutaneous Lupus Background/Purpose Lupus erythematosus panniculitis (LEP) is a rare form of chronic cutaneous lupus erythematosus characterized by indurated nodules or plaques resulting in pronounced skin atrophy. Calcinosis cutis (CC) is a disease sequela associated with LEP, leading to the significant impact on patients’ quality of life due to pain and limited treatment options. The frequency of development and risk factors associated with CC in LEP remain unclear. This study aims to assess the rate of CC in LEP patients and identify factors that may increase development of CC, thereby providing insights into monitoring and management strategies for LEP patients. Methods This retrospective cohort study reviewed data from 26 patients diagnosed with LEP and treated at the outpatient dermatology clinics of the University of Texas Southwestern Medical Center and Parkland Health between April 2009 and August 2024. The primary outcome measure was the presence of CC, confirmed through clinical evaluation by a dermatologist, biopsy, or imaging. Patient data included demographic details, smoking history, disease duration, lesion location, medications, and ANA positivity. Frequency counts and medians were calculated for categorical and continuous variables, respectively. We analyzed predictor variables for presence of CC using Mann-Whitney U and Fisher’s exact tests to examine associations. Results Of the 26 LEP patients, 10 (38%) were diagnosed with CC (Table 1). For these 10 patients, the median duration after diagnosis of LEP to diagnosis of CC was 3.98 years. LEP Patients that were diagnosed with calcinosis cutis had greater LEP involvement of their trunk, with 9/10 (90%) patients with LEP truncal involvement having CC, compared to only 5/16 (31%) in the group that did not have CC (p=0.01) (Table 2). The CC lesions on the 10 patients that developed this sequela were found predominantly on the trunk (6) and arms (5). No significant associations were found between CC development and other variables, including demographic factors, ANA positivity, smoking history, medications, and follow-up duration (Table 1). Table 1: Univariate analysis of demographics and clinical risk factors of lupus erythematosus panniculitis (LEP) patients with and without calcinosis cutis (CC) Table 2: Body site involvement of lupus erythematosus panniculitis (LEP) lesions in LEP patients with and without calcinosis cutis (CC) Conclusions In one of the larger cohorts of LEP patients studied to date, over one-third had CC, and truncal lesions, such as those in the chest and buttocks, were significantly correlated with this complication. The median disease duration from LEP diagnosis to CC diagnosis was about 4 years. The substantial occurrence of CC in LEP highlights the need for vigilant clinical monitoring of CC in LEP. This study is limited by its single-center, retrospective design, and small sample size. Further prospective studies with larger sample sizes are necessary to confirm these results and clarify the timing and mechanisms behind CC development in LEP patients.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».