CALCINOSIS CUTIS IN LUPUS ERYTHEMATOSUS PANNICULITIS SHOW PREDILECTION FOR TRUNCAL LOCATION
Bibliographic record
Abstract
PV061 / #136 Poster Topic: AS07 - Cutaneous Lupus Background/Purpose Lupus erythematosus panniculitis (LEP) is a rare form of chronic cutaneous lupus erythematosus characterized by indurated nodules or plaques resulting in pronounced skin atrophy. Calcinosis cutis (CC) is a disease sequela associated with LEP, leading to the significant impact on patients’ quality of life due to pain and limited treatment options. The frequency of development and risk factors associated with CC in LEP remain unclear. This study aims to assess the rate of CC in LEP patients and identify factors that may increase development of CC, thereby providing insights into monitoring and management strategies for LEP patients. Methods This retrospective cohort study reviewed data from 26 patients diagnosed with LEP and treated at the outpatient dermatology clinics of the University of Texas Southwestern Medical Center and Parkland Health between April 2009 and August 2024. The primary outcome measure was the presence of CC, confirmed through clinical evaluation by a dermatologist, biopsy, or imaging. Patient data included demographic details, smoking history, disease duration, lesion location, medications, and ANA positivity. Frequency counts and medians were calculated for categorical and continuous variables, respectively. We analyzed predictor variables for presence of CC using Mann-Whitney U and Fisher’s exact tests to examine associations. Results Of the 26 LEP patients, 10 (38%) were diagnosed with CC (Table 1). For these 10 patients, the median duration after diagnosis of LEP to diagnosis of CC was 3.98 years. LEP Patients that were diagnosed with calcinosis cutis had greater LEP involvement of their trunk, with 9/10 (90%) patients with LEP truncal involvement having CC, compared to only 5/16 (31%) in the group that did not have CC (p=0.01) (Table 2). The CC lesions on the 10 patients that developed this sequela were found predominantly on the trunk (6) and arms (5). No significant associations were found between CC development and other variables, including demographic factors, ANA positivity, smoking history, medications, and follow-up duration (Table 1). Table 1: Univariate analysis of demographics and clinical risk factors of lupus erythematosus panniculitis (LEP) patients with and without calcinosis cutis (CC) Table 2: Body site involvement of lupus erythematosus panniculitis (LEP) lesions in LEP patients with and without calcinosis cutis (CC) Conclusions In one of the larger cohorts of LEP patients studied to date, over one-third had CC, and truncal lesions, such as those in the chest and buttocks, were significantly correlated with this complication. The median disease duration from LEP diagnosis to CC diagnosis was about 4 years. The substantial occurrence of CC in LEP highlights the need for vigilant clinical monitoring of CC in LEP. This study is limited by its single-center, retrospective design, and small sample size. Further prospective studies with larger sample sizes are necessary to confirm these results and clarify the timing and mechanisms behind CC development in LEP patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".